The role of small dense LDL-C/large buoyant LDL-C ratio as an independent risk factor in patients with type 2 diabetes mellitus and metabolic syndrome

被引：1

作者：

Wang, Cui ^{[1
]}

Li, Yaoze ^{[2
]}

Lin, Hao ^{[3
]}

Zhu, Yulin ^{[1
]}

Xu, Xiangdong ^{[4
]}

Wu, PingPing ^{[1
]}

Zhang, Yali ^{[1
]}

Xu, Ting ^{[1
]}

Ren, Jian ^{[1
]}

Xu, Haibo ^{[1
]}

Dong, Guoyu ^{[1
]}

Xu, Yue ^{[5
,6
]}

Jiang, Huihui ^{[5
,6
]}

Zhao, Jiangman ^{[5
,6
]}

Zhai, Yufeng ^{[5
,6
]}

Peng, Pei ^{[5
,6
]}

Zai, Guotian

机构：

[1] Nantong Univ, Nanjing jiangbei Hosp, Dept Endocrinol & Metab, Nanjing 210048, Peoples R China

[2] Queshan Cty Peoples Hosp, Dept Oncol, Zhumadian 463200, Henan, Peoples R China

[3] Nantong Univ, Nanjing Jiangbei Hosp, Dept Gen Surg, Nanjing 210048, Peoples R China

[4] Peoples Hosp Queshan Cty, Dept Neurol, Zhumadian 463200, Henan, Peoples R China

[5] Shanghai Biotecan Pharmaceut Co Ltd, Shanghai 201204, Peoples R China

[6] Shanghai Zhangjiang Institue Med Innovat, Shanghai 201204, Peoples R China

来源：

ANNALES DE BIOLOGIE CLINIQUE | 2024年 / 82卷 / 02期

关键词：

type 2 diabetes mellitus; metabolic syndrome; sdLDL-C/lbLDL-C; risk factor; dyslipidemia; INSULIN-RESISTANCE; LIPOPROTEINS; IDENTIFICATION; CLASSIFICATION; INDIVIDUALS; ASSOCIATION; CHOLESTEROL; DEFINITION; PREDICTOR; DIAGNOSIS;

D O I：

10.1684/abc.2024.1883

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background: Dyslipidemia plays a key role in metabolic syndrome (MS), intricately linked to type 2 diabetes mellitus (T2DM). Objective: This study aimed to investigate the differences in low-density lipoprotein cholesterol (LDL-C) subfraction levels between T2DM and T2DM with MS, and identify the risk factors associated with the disease. Methods: A total of 246 individuals diagnosed with T2DM, including 144 T2DM patients with MS, and 147 healthy subjects were recruited. All participants underwent a comprehensive clinical evaluation. Lipoprotein subfraction analysis was performed using the Lipoprint LDL system. Results: Multivariate logistic regression analysis revealed that several lipid markers, including triglyceride (TG), LDL-C, large buoyant LDL-C (lbLDLC), small dense LDL-C (sdLDL-C), LDLC2-5, and sdLDL-C/lbLDL-C ratio, were identified as independent risk factors for T2DM. Additionally, TG, sdLDL-C, LDLC-4, LDLC-5, and sdLDL-C/lbLDL-C ratio were found to be independent risk factors for T2DM with MS. Furthermore, the results of the receiver operating characteristic (ROC) curves demonstrated that sdLDL-C, LDLC-4, LDLC-3, and sdLDL-C/lbLDL-C ratio exhibited excellent predictive performance for the risk of T2DM (AUC > 0.9). Conclusion: The sdLDL-C/lbLDL-C ratio emerges as a shared independent risk factor for T2DM and MS complications. Furthermore, sdLDL-C/lbLDL-C ratio, along with LDL-4 and LDL-3, exhibits noteworthy predictive capabilities for T2DM.

引用

页码：174 / 186

页数：13

共 30 条

[1]

Amer Diabet Assoc, 2013, DIABETES CARE, V36, pS67, DOI [10.2337/dc13-S067, 10.2337/dc11-S011, 10.2337/dc10-S011, 10.2337/dc14-S081, 10.2337/dc12-s064, 10.2337/dc12-s011, 10.2337/dc11-S062, 10.2337/dc13-S011, 10.2337/dc10-S062]

[2] High incidence of type 1 diabetes, type 2 diabetes and gestational diabetes in Central Iran: A six years results from Semnan health cohort [J].

Babakhanian, Masoudeh ;

Razavi, Alireza ;

Pordanjani, Sajad Rahimi ;

Hassanabadi, Sepehr ;

Mohammadi, Gholamreza ;

Fattah, Abolfazl .

ANNALS OF MEDICINE AND SURGERY, 2022, 82

[3] Low-density lipoprotein 4: a novel predictor of coronary artery disease severity [J].

Chaudhary, Rahul ;

Mathew, Denny ;

Bliden, Kevin ;

Tantry, Udaya S. ;

Sharma, Tushar ;

Gesheff, Martin G. ;

Franzese, Christopher J. ;

Pandya, Shachi ;

Toth, Peter P. ;

Gurbel, Paul A. .

CURRENT MEDICAL RESEARCH AND OPINION, 2017, 33 (11) :1979-1984

[4] Metabolic syndrome in north Indian type 2 diabetes mellitus patients: A comparison of four different diagnostic criteria of metabolic syndrome [J].

Gahlan, Deepak ;

Rajput, Rajesh ;

Singh, Vandana .

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS, 2019, 13 (01) :356-362

[5] CD36 Gene Variants and Their Association with Type 2 Diabetes in an Indian Population [J].

Gautam, Sunaina ;

Pirabu, Loganathan ;

Agrawal, Chandra G. ;

Banerjee, Monisha .

DIABETES TECHNOLOGY & THERAPEUTICS, 2013, 15 (08) :680-687

[6] Familial dyslipidaemias - An overview of genetics, pathophysiology and management [J].

Hachem, Sahar B. ;

Mooradian, Arhag D. .

DRUGS, 2006, 66 (15) :1949-1969

[7] Elevated Serum Small Dense Low-Density Lipoprotein Cholesterol May Increase the Risk and Severity of Coronary Heart Disease and Predict Cardiovascular Events in Patients with Type 2 Diabetes Mellitus [J].

Huang, Juan ;

Gu, Jun-Xu ;

Bao, Hui-Zhang ;

Li, Shan-Shan ;

Yao, Xiao-Qin ;

Yang, Ming ;

Li, Yang ;

Zhang, Ai-Min ;

Yin, Yue ;

Zhang, Na ;

Jia, Mei ;

Su, Ming .

DISEASE MARKERS, 2021, 2021

[8] Increased small low-density lipoprotein particle number - A prominent feature of the metabolic syndrome in the Framingham Heart Study [J].

Kathiresan, S ;

Otvos, JD ;

Sullivan, LM ;

Keyes, MJ ;

Schaefer, EJ ;

Wilson, PWF ;

D'Agostino, RB ;

Vasan, RS ;

Robins, SJ .

CIRCULATION, 2006, 113 (01) :20-29

[9] Definition, Classification and Diagnosis of Diabetes Mellitus [J].

Kerner, W. ;

Brueckel, J. .

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 2014, 122 (07) :384-386

[10] Small dense LDL cholesterol measured by homogeneous assay in Japanese healthy controls, metabolic syndrome and diabetes patients with or without a fatty liver [J].

Kikkawa, Koji ;

Nakajima, Katsuyuki ;

Shimomura, Younosuke ;

Tokita, Yoshiharu ;

Machida, Tetsuo ;

Sumino, Hiroyuki ;

Murakami, Masami .

CLINICA CHIMICA ACTA, 2015, 438 :70-79

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