Immunotherapy and Radiotherapy Combinations for Sarcoma

被引：2

作者：

Zhang, Qian S. ^{[1
]}

Hayes, John P. ^{[1
]}

Gondi, Vinai ^{[1
]}

Pollack, Seth M. ^{[2
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Dept Radiat Oncol, Chicago, IL 60611 USA

[2] Northwestern Univ, Feinberg Sch Med, Dept Med, Div Oncol, 303 E Super St 3-115, Chicago, IL 60611 USA

来源：

SEMINARS IN RADIATION ONCOLOGY | 2024年 / 34卷 / 02期

关键词：

SOFT-TISSUE SARCOMA; ADJUVANT RADIATION-THERAPY; OPEN-LABEL; T-CELLS; CHECKPOINT BLOCKADE; METASTATIC SARCOMA; ANTITUMOR-ACTIVITY; IMMUNE-MECHANISMS; LOCAL RADIATION; BREAST-CANCER;

D O I：

10.1016/j.semradonc.2023.12.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Sarcomas are a heterogeneous group of bone and soft tissue tumors. Survival outcomes for advanced (unresectable or metastatic) disease remain poor, so therapeutic improvements are needed. Radiotherapy plays an integral role in the neoadjuvant and adjuvant treatment of localized disease as well as in the treatment of metastatic disease. Combining radiotherapy with immunotherapy to potentiate immunotherapy has been used in a variety of cancers other than sarcoma, and there is opportunity to further investigate combining immunotherapy with radiotherapy to try to improve outcomes in sarcoma. In this review, we describe the diversity of the tumor immune microenvironments for sarcomas and describe the immunomodulatory effects of radiotherapy. We discuss studies on the timing of radiotherapy relative to immunotherapy and studies on the radiotherapy dose and fractionation regimen to be used in combination with immunotherapy. We describe the impact of radiotherapy on the tumor immune microenvironment. We review completed and ongoing clinical trials combining radiotherapy with immunotherapy for sarcoma and propose future directions for studies combining immunotherapy with radiotherapy in the treatment of sarcoma. Semin Radiat Oncol 34:229 -242 (c) 2023 Elsevier Inc. All rights reserved.

引用

页码：229 / 242

页数：14

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