Oral Anaerobutyricum soehngenii augments glycemic control in type 2 diabetes

被引：3

作者：

Attaye, Ilias ^{[1
,2
,3
]}

Witjes, Julia J. ^{[1
,2
,3
]}

Koopen, Annefleur M. ^{[1
,2
,3
]}

van der Vossen, Eduard W. J. ^{[1
]}

Zwirs, Diona ^{[1
]}

Wortelboer, Koen ^{[1
,2
,3
]}

Collard, Didier ^{[1
]}

Kemper, Elles Marleen ^{[4
]}

Winkelmeijer, Maaike ^{[1
,5
]}

Holst, Jens J. ^{[6
,7
]}

Hazen, Stanley L. ^{[2
,8
]}

Kuipers, Folkert ^{[9
]}

Stroes, Erik S. G. ^{[1
]}

Groen, Albert K. ^{[1
]}

de Vos, Willem M. ^{[10
,11
]}

Nieuwdorp, Max ^{[1
]}

Herrema, Hilde ^{[1
,2
,3
]}

机构：

[1] Univ Amsterdam, Med Ctr, Dept Vasc Med, Amsterdam, Netherlands

[2] Amsterdam Cardiovasc Sci Diabet & Metab, Amsterdam, Netherlands

[3] Amsterdam Gastroenterol Endocrinol Metab Endocrino, Amsterdam, Netherlands

[4] Univ Amsterdam, Med Ctr, Dept Pharm & Clin Pharmacol, Amsterdam, Netherlands

[5] Univ Amsterdam, Med Ctr, Dept Expt Vasc Med, Amsterdam, Netherlands

[6] Univ Copenhagen, NNF Ctr Basic Metab Res, Copenhagen, Denmark

[7] Univ Copenhagen, Dept Biomed Sci, Copenhagen, Denmark

[8] Cleveland Clin, Lerner Res Inst, Dept Cardiovasc & Metab Sci, Cleveland Hts, OH 44195 USA

[9] Univ Groningen, Univ Med Ctr Groningen, European Res Inst Biol Ageing ERIBA, Dept Pediat, Groningen, Netherlands

[10] Wageningen Univ, Wageningen, Netherlands

[11] Univ Helsinki, Fac Med, Human Microbiome Res Program, Helsinki, Finland

来源：

ISCIENCE | 2024年 / 27卷 / 08期

关键词：

GUT MICROBIOTA; INSULIN SENSITIVITY; METFORMIN; BUTYRATE; LACTATE; SYSTEM; ALTERS; FECES; WOMEN;

D O I：

10.1016/j.isci.2024.110455

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This randomized, double-blind, placebo-controlled trial investigated the impact of 14-day Anaerobutyricum soehngenii L2-7 supplementation on postprandial glucose levels in 25 White Dutch males with type 2 diabetes (T2D) on stable metformin therapy. The primary endpoint was the effect of A. soehngenii versus placebo on glucose excursions and variability as determined by continuous glucose monitoring. Secondary endpoints were changes in ambulatory 24-h blood pressure, incretins, circulating metabolites and excursions of plasma short-chain fatty acids (SCFAs) and bile acids upon a standardized meal. Results showed that A. soehngenii supplementation for 14 days significantly improved glycemic variability and mean arterial blood pressure, without notable changes in SCFAs, bile acids, incretin levels, or anthropometric parameters as compared to placebo-treated controls. Although well-tolerated and effective in improving glycemic control in the intervention group, further research in larger and more diverse populations is needed to generalize these findings.

引用

页数：14

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