Effect of Alaska pollock-gelatin sheet on repair strength and regeneration of nerve

被引：0
作者：
Tsujisaka, Ryosuke [1 ]
Suzuki, Taku [1 ]
Shibata, Shinsuke [2 ]
Iwamoto, Takuji [1 ]
Taguchi, Tetsushi [3 ,4 ]
Nakamura, Masaya [1 ]
机构：
[1] Keio Univ, Dept Orthoped Surg, Sch Med, 35 Shinano Machi,Shinjuku Ku, Tokyo 1608582, Japan
[2] Keio Univ, Sch Med, Elect Microscope Lab, Tokyo, Japan
[3] Univ Tsukuba, Grad Sch Pure & Appl Sci, Ibaraki, Japan
[4] Natl Inst Mat Sci, Funct Mat Res Ctr, Polymers & Biomat Field, Ibaraki, Japan
来源：
JOURNAL OF HAND SURGERY-EUROPEAN VOLUME | 2025年 / 50卷 / 01期
基金：
日本学术振兴会;
关键词：
Alaska pollock-gelatin; Alaska pollock-gelatin sealant; Alaska pollock-gelatin sheet; fibrin glue; nerve; sealant; FIBRIN SEALANT; GLUE; RESISTANCE; SUTURE;
D O I：
10.1177/17531934241251670
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
The aim of the study was to investigate the repair strength and the biocompatibility of Alaska pollock-derived gelatin (ApGltn) sheet for nerve repair. Cadaveric digital nerves were repaired with double suture, single suture+ApGltn sheet, single suture+fibrin glue, single suture, ApGltn sheet and fibrin. Maximum failure loads were measured (20 nerves each). Rat sciatic nerves were repaired with double suture, single suture+ApGltn sheet, single suture, ApGltn sheet, fibrin glue and resection (10 nerves each). Macroscopic appearance, muscle weight and histopathological findings were examined 8 weeks postoperatively. The mean failure load of ApGltn sheet (0.39N) was significantly higher than that of a fibrin (0.05N), and that of single suture+ApGltn sheet (1.32N) was significantly higher than that of a single suture alone (0.97N). Functional and histological assessments showed similar nerve recovery among the suture, ApGltn and fibrin groups. ApGltn sheet has potential for clinical application as an alternative to fibrin.
引用
收藏
页码：76 / 84
页数：9
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