Mechanism of selective laser trabeculoplasty: a systemic review

被引：2

作者：

Chen, Yu-Feng ^{[1
]}

Zeng, Wen ^{[1
]}

机构：

[1] Wuhan Univ, Dept Ophthalmol, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China

来源：

INTERNATIONAL JOURNAL OF OPHTHALMOLOGY | 2024年 / 17卷 / 05期

关键词：

mechanisms; selective laser trabeculoplasty; glaucoma; trabecular meshwork; TRABECULAR MESHWORK CELLS; OPEN-ANGLE GLAUCOMA; OCULAR HYPERTENSION; AQUEOUS OUTFLOW; ENDOTHELIAL-CELLS; IN-VITRO; PIGMENTATION; PREDICTORS; EFFICACY;

D O I：

10.18240/ijo.2024.05.22

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Although selective laser trabeculoplasty (SLT) is a recognized method for the treatment of glaucoma, the exact changes in the target tissue and mechanism for its intraocular pressure lowing effect are still unclear. The purpose of this review is to summarize the potential mechanisms of SLT on trabecular meshwork both in vivo and in vitro, so as to reveal the potential mechanism of SLT. SLT may induce immune or inflammatory response in trabecular meshwork (TM) induced by possible oxidative damage etc , and remodel extracellular matrix. It may also induce monocytes to aggregate in TM tissue, increase Schlemm's canal (SC) cell conductivity, disintegrate cell junction and promote permeability through autocrine and paracrine forms. This provides a theoretical basis for SLT treatment in glaucoma.

引用

页码：963 / 968

页数：6

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