Early-Onset Colorectal Cancer in Egypt: Pathological Characters, Patterns of Care, and Survival Compared to Average-Age Onset Colorectal Cancer: A Retrospective Multicenter Study

被引：2

作者：

Rashad, Noha ^{[1
,2
]}

Salem, Salem Eid ^{[3
]}

Meheissen, Mohamed A. M. ^{[4
,5
]}

Refaat, Ghada ^{[6
]}

Mahmoud Sami, Heba ^{[3
]}

Temerik, Abdelsalam ^{[1
]}

Kordy, Nashwa ^{[7
]}

Daniel, Mina A. ^{[1
]}

El-Kaffas, Mohamed ^{[1
]}

Esam, Mohamed ^{[1
]}

El Mansy, Hazem ^{[8
,9
]}

Elkerm, Yasser ^{[8
,9
]}

Abdelaziz Elsaid, Amr ^{[4
,9
]}

Ismail, Abdelsalam Attia ^{[4
,9
]}

Abdelhalim, Mohyeldin Saber ^{[4
]}

Ahmad, Lamiaa Moustafa ^{[6
]}

Mahmoud, Mai Akram ^{[6
]}

El Desouky, Eman D. ^{[10
]}

机构：

[1] Shefaa Al Orman Oncol Hosp, Med Oncol Dept, Luxor, Egypt

[2] Suez Univ, Fac Med, Clin Oncol Dept, Suez, Egypt

[3] Cairo Univ, Natl Canc Inst NCI, Dept Med Oncol, Cairo 11796, Egypt

[4] Alexandria Univ, Fac Med, Clin Oncol Dept, Alexandria, Egypt

[5] Hope Canc Ctr, Alexandria, Egypt

[6] Ain Shams Univ, Fac Med, Clin Oncol & Nucl Med Dept, Cairo, Egypt

[7] Shefaa Al Orman Oncol Hosp, Biostat Epidemiol & Sci Comp Dept, Luxor, Egypt

[8] Univ Alexandria, Med Res Inst, Dept Canc Management & Res, Alexandria, Egypt

[9] Specialized Universal Network Oncol SUN, Alexandria, Egypt

[10] Cairo Univ, Natl Canc Inst, Dept Biostat & Epidemiol, Cairo, Egypt

来源：

JCO GLOBAL ONCOLOGY | 2024年 / 10卷

关键词：

INCREASING INCIDENCE; YOUNG-ADULTS; COLON-CANCER; RISK;

D O I：

10.1200/GO.23.00372

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

PURPOSE Early-onset colorectal cancer (EOCRC) is a rising health problem. The incidence of EOCRC has increased over the past 2 decades all over the world. Reports from Egypt since the 1990s have reported a higher incidence among young populations with no identifiable risk factors. The aim of this study was to assess EOCRC in Egypt regarding incidence, characteristics, treatment pattern, and survival compared with average age onset and elderly patients. MATERIALS AND METHODS This was a retrospective, record-based, cohort study combining data from four different cancer centers in Egypt. We grouped patients according to age into three categories: the EOCRC group for patients age <= 45 years and the average age onset and elderly cancer group (for patients age >= 65 years). RESULTS The study included 1,310 patients with histopathologically proven colorectal cancer, representing four different geographical areas in Egypt. Patients with EOCRC represented 42.4% of the study population. Female patients were 50.6% among the EOCRC group and 52.5% among the average age group. Rectal tumors were significantly higher in EOCRC (54.7% v 40.6%; P < .001). There was no significant difference between both groups regarding the tumor stage at presentation, obstruction, or presence of metastases at presentation. Patients with EOCRC had a significantly higher rate of peritoneum/adnexa metastases than the average age ones (12.3% in EOCRC v 6.9% in the average age group; P < .001). No statistically significant differences between EOCRC and average age groups in both disease-free survival and overall survival were reported. CONCLUSION A comprehensive framework for the study of EOCRC is required in Egypt as well as a genomic analysis to identify possible underlying genetic alterations responsible for the high incidence of EOCRC.

引用

页数：8