Cardioprotective effect of cedrol in an inflammation systemic model induced by lipopolysaccharide: Biochemical and histological verification

被引:0
作者
Rastegar-Moghaddam, Seyed Hamidreza [1 ]
Amirahmadi, Sabiheh [2 ]
Akbarian, Mahsan [3 ]
Sharizina, Matin [4 ]
Beheshti, Farimah [5 ,6 ]
Rajabian, Arezoo [7 ]
Ghalibaf, Mohammad Hosein Eshaghi [2 ]
Azimi, Mohaddeseh [3 ]
Mahmoudabady, Maryam [3 ,5 ]
Hosseini, Mahmoud [2 ,3 ,7 ]
机构
[1] Mashhad Univ Med Sci, Fac Med, Dept Anat & Cell Biol, Mashhad, Iran
[2] Mashhad Univ Med Sci, Psychiat & Behav Sci Res Ctr, Mashhad, Iran
[3] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran
[4] Mashhad Univ Med Sci, Fac Med, Dept Physiol, Mashhad, Iran
[5] Torbat Heydariyeh Univ Med Sci, Neurosci Res Ctr, Torbat Heydariyeh, Iran
[6] Torbat Heydariyeh Univ Med Sci, Sch Med, Dept Physiol, Torbat Heydariyeh, Iran
[7] Mashhad Univ Med Sci, Neurosci Res Ctr, Mashhad, Iran
关键词
Lipopolysaccharide; Cedrol; Heart; Inflammation; Fibrosis; Oxidative stress; INDUCED OXIDATIVE STRESS; MYOCARDIAL-INFARCTION; CARDIAC FIBROBLASTS; FIBROSIS; MONTELUKAST; EXPRESSION; CYTOKINES; ARTHRITIS; RESPONSES; MYOCYTES;
D O I
10.34172/jcvtr.33112
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction: Evidence declared lipopolysaccharide (LPS) initiates inflammatory responses by stimulating the abandon of cytokines, which may perturb organ function. On the other side, it has been suggested Cedrol has potential properties, including anti-inflammatory and anti- oxidative activities. Herein, this study was done to assess the protective effect of Cedrol against LPS-associated heart damage. Methods: Thirty-five rats (200-250 g) were sorted into five groups, including control, LPS, LPS-Cedrol 7.5 mg/kg, LPS-Cedrol 15 mg/kg, and LPS-Cedrol 30 mg/kg groups. Cedrol was administrated through injected intra-peritoneally for two weeks. The heart tissues were removed and malondialdehyde (MDA) as a lipid peroxidation marker, superoxide dismutase (SOD), and catalase (CAT) as antioxidant markers were assessed. Furthermore, the interleukin (IL)-6 level in cardiac tissue was measured and Masson's trichrome methods were employed to appraise cardiac inflammation and fibrosis, respectively. Results: Inflammation induced by LPS was significantly accompanied by myocardial fibrosis which was shown by Masson's trichrome staining (P < 0.001). In addition, LPS administration enhanced the MDA level while it diminished the activity of anti-oxidant markers such as CAT and SOD (P < 0.001 for all cases). In the histological results, Cedrol improved LPS-induced inflammation and cardiac fibrosis (P< 0.01 to P < 0.001). Cedrol also enhanced CAT and SOD activities, whereas declined MDA level in the cardiac tissue (P< 0.01 to P< 0.001). Conclusion: The current findings proposed that the administration of Cedrol exerted a protective role in LPS-associated heart damage by reducing inflammation, cardiac fibrosis, and oxidative stress.
引用
收藏
页码:120 / 128
页数:9
相关论文
共 58 条
  • [1] Abareshi A, 2017, INT J PREVENTIVE MED, V8, DOI 10.4103/ijpvm.IJPVM_322_16
  • [2] AEBI H, 1984, METHOD ENZYMOL, V105, P121
  • [3] A protective effect of curcumin on cardiovascular oxidative stress indicators in systemic inflammation induced by lipopolysaccharide in rats
    Ahmadabady, Somaieh
    Beheshti, Farimah
    Shahidpour, Fatemeh
    Khordad, Elnaz
    Hosseini, Mahmoud
    [J]. BIOCHEMISTRY AND BIOPHYSICS REPORTS, 2021, 25
  • [4] Minocycline attenuates cholinergic dysfunction and neuro-inflammation-mediated cognitive impairment in scopolamine-induced Alzheimer's rat model
    Amirahmadi, Sabiheh
    Farimani, Faezeh Dabouri
    Akbarian, Mahsan
    Mirzavi, Farshad
    Ghalibaf, Mohammad Hossein Eshaghi
    Rajabian, Arezoo
    Hosseini, Mahmoud
    [J]. INFLAMMOPHARMACOLOGY, 2022, 30 (06) : 2385 - 2397
  • [5] Cardiac and renal fibrosis and oxidative stress balance in lipopolysaccharide-induced inflammation in male rats
    Asgharzadeh, Fereshteh
    Bargi, Rahimeh
    Hosseini, Mahmoud
    Farzadnia, Mehdi
    Khazaei, Majid
    [J]. ARYA ATHEROSCLEROSIS, 2018, 14 (02) : 71 - 77
  • [6] ROS generation, oxidative burst and dynamic expression profiles of ROS-scavenging enzymes of superoxide dismutase (SOD), catalase (CAT) and ascorbate peroxidase (APX) in response to Erwinia amylovora in pear (Pyrus communis L)
    Azarabadi, Saeidreza
    Abdollahi, Hamid
    Torabi, Mohamad
    Salehi, Zeynab
    Nasiri, Jaber
    [J]. EUROPEAN JOURNAL OF PLANT PATHOLOGY, 2017, 147 (02) : 279 - 294
  • [7] Innate immune sensing and its roots: the story of endotoxin
    Beutler, B
    Rietschel, ET
    [J]. NATURE REVIEWS IMMUNOLOGY, 2003, 3 (02) : 169 - 176
  • [8] RETRACTED: Puerarin Attenuates LPS-Induced Inflammatory Responses and Oxidative Stress Injury in Human Umbilical Vein Endothelial Cells through Mitochondrial Quality Control (Retracted article)
    Chang, Xing
    Zhang, Tian
    Liu, Dong
    Meng, Qingyan
    Yan, Peizheng
    Luo, Duosheng
    Wang, Xue
    Zhou, XiuTeng
    [J]. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2021, 2021
  • [9] Chen X, 2020, FOOD FUNCT, V11, P4752, DOI [10.1039/D0FO00549E, 10.1039/d0fo00549e]
  • [10] The Effects of Montelukast on Antioxidant Enzymes and Proinflammatory Cytokines on the Heart, Liver, Lungs, and Kidneys in a Rat Model of Cecal Ligation and Puncture-Induced Sepsis
    Coskun, Ali Kagan
    Yigiter, Murat
    Oral, Akgun
    Odabasoglu, Fehmi
    Halici, Zekai
    Mentes, Oner
    Cadirci, Elif
    Atalay, Fadime
    Suleyman, Halis
    [J]. THESCIENTIFICWORLDJOURNAL, 2011, 11 : 1341 - 1356