Association of IL-6-572 polymorphism with sepsis: An updated meta-analysis

被引：0
作者：
Hou, Fang [1 ]
Gao, Jing [2 ]
Zhang, Li [2 ]
Liu, Chang [3 ]
机构：
[1] Xinjiang Med Univ, Dept Intens Care Unit, Affiliated Hosp 1, Urumqi, Xinjiang, Peoples R China
[2] Xinjiang Med Univ, Dept Nursing, Affiliated Hosp 1, Urumqi, Xinjiang, Peoples R China
[3] Xinjiang Med Univ, Dept Oncol, Affiliated Hosp 1, Urumqi, Xinjiang, Peoples R China
来源：
CYTOKINE | 2024年 / 179卷
关键词：
IL-6-572; polymorphism; Sepsis; Systematic review; Meta; -analysis; INTERNATIONAL CONSENSUS DEFINITIONS; SEPTIC SHOCK; INTERLEUKIN-6; GUIDELINES;
D O I：
10.1016/j.cyto.2024.156597
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Objectives: To analyze the relationship between IL and 6 572C/G polymorphism with sepsis. Methods: Searching 8 databases the Cochrane Library, China National Knowledge Infrastructure (CNKI), China Biology Medicine (CBM), Chongqing VIP, Embase, PubMed, WanFang Data, and Web of Science from inception to October 1, 2023. Meta-analysis was performed by using Review Manager 5.4 and STATA 15.0. Results: 9 studies were included, 1 study was excluded from the previous meta-analysis, and 6 studies were added. Sensitivity analysis suggested that the results were relatively robust. The P values of Egger test indicated that no conspicuous publication bias was found. Conclusion: According to the meta-analysis results of existing studies, the IL-6 572C/G GG genotype and G allele are risk factors for sepsis, this result changes the previous conclusion that the IL-6 572 polymorphism is not related to sepsis. However, the results still need to be conservatively treated due to the sample size was not large enough.
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