Nickel-Catalyzed Enantioselective Reductive Arylation of Common Ketones

被引：11

作者：

Huang, Shuai ^{[1
]}

Zhou, Jianrong Steve ^{[1
]}

机构：

[1] Peking Univ, Sch Chem Biol & Biotechnol, Shenzhen Grad Sch, State Key Lab Chem Oncogen, Shenzhen 518055, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2024年 / 146卷 / 19期

基金：

中国国家自然科学基金;

关键词：

CHIRAL BIS(OXAZOLINE) LIGANDS; COUPLING REACTIONS; ORGANOZINC REAGENTS; ASYMMETRIC ADDITION; GRIGNARD-REAGENTS; TERTIARY ALCOHOLS; ARYL; HALIDES; MECHANISMS; COMPLEXES;

D O I：

10.1021/jacs.4c02818

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A nickel complex of chiral bisoxazolines catalyzed the stereoselective reductive arylation of ketones in high enantioselectivity. A range of common acyclic and cyclic ketones reacted without the aid of directing groups. Mechanistic studies using isolated complex of a chiral bis(oxazoline) (L)Ni(Ar)Br revealed that Mn reduction was not needed, while Lewis acidic titanium alkoxides were critical to ketone insertion.

引用

页码：12895 / 12900

页数：6