Nickel-Catalyzed Enantioselective Reductive Arylation of Common Ketones

被引：11
作者：
Huang, Shuai [1 ]
Zhou, Jianrong Steve [1 ]
机构：
[1] Peking Univ, Sch Chem Biol & Biotechnol, Shenzhen Grad Sch, State Key Lab Chem Oncogen, Shenzhen 518055, Peoples R China
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2024年 / 146卷 / 19期
基金：
中国国家自然科学基金;
关键词：
CHIRAL BIS(OXAZOLINE) LIGANDS; COUPLING REACTIONS; ORGANOZINC REAGENTS; ASYMMETRIC ADDITION; GRIGNARD-REAGENTS; TERTIARY ALCOHOLS; ARYL; HALIDES; MECHANISMS; COMPLEXES;
D O I：
10.1021/jacs.4c02818
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A nickel complex of chiral bisoxazolines catalyzed the stereoselective reductive arylation of ketones in high enantioselectivity. A range of common acyclic and cyclic ketones reacted without the aid of directing groups. Mechanistic studies using isolated complex of a chiral bis(oxazoline) (L)Ni(Ar)Br revealed that Mn reduction was not needed, while Lewis acidic titanium alkoxides were critical to ketone insertion.
引用
收藏
页码：12895 / 12900
页数：6
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