Active Surveillance in Metastatic Renal Cell Carcinoma

被引：3

作者：

Beecroft, Nicholas ^{[1
]}

Gauntner, Timothy D. ^{[2
]}

Upadhyay, Rituraj ^{[3
]}

Wang, Shang-Jui ^{[3
]}

Yang, Yuanquan ^{[2
]}

Singer, Eric A. ^{[1
]}

Dason, Shawn ^{[1
,4
]}

机构：

[1] Ohio State Univ, Comprehens Canc Ctr, Div Urol Oncol, Columbus, OH USA

[2] Ohio State Univ, Comprehens Canc Ctr, Div Med Oncol, Columbus, OH USA

[3] Ohio State Univ, Comprehens Canc Ctr, Dept Radiat Oncol, Columbus, OH USA

[4] Div Urol Oncol, 2121 Kenny Rd,7th Floor, Columbus, OH 43210 USA

来源：

JOURNAL OF KIDNEY CANCER AND VHL | 2024年 / 11卷 / 02期

关键词：

active surveillance; cytoreductive nephrectomy; metastatic renal cell carcinoma; radiation therapy; systemic therapy; KIDNEY CANCER; PHASE-II; NIVOLUMAB; CABOZANTINIB; GUIDELINES; IPILIMUMAB; SURVIVAL; THERAPY;

D O I：

10.15586/jkcvhl.v11i2.309

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Metastatic renal cell carcinoma (mRCC) is a heterogenous disease with a variable clinical course. While therapies for treatment of this condition have progressed, they are not without toxicity. In some patients, active surveillance (AS) of this disease is increasingly considered to delay its toxicity. This article seeks to review the literature and discuss management of metastatic renal cell carcinoma, specifically regarding upfront AS, the role of radiation therapy in delaying systemic therapy, and surveillance after initial treatment with systemic therapy. Median time on AS prior to initiation of systemic therapy ranged from 14 to 60 months across studies. AS is appropriate to offer in favorable or intermediate risk, asymptomatic, and systemic treatment na & iuml;ve patients with mRCC.

引用

页码：27 / 38

页数：12

共 44 条

[1]

Atkins MB, 2023, J CLIN ONCOL, V41

[2] Phase II Study of Nivolumab and Salvage Nivolumab/Ipilimumab in Treatment-Naive Patients With Advanced Clear Cell Renal Cell Carcinoma (HCRN GU16-260-Cohort A) [J].

Atkins, Michael B. ;

Jegede, Opeyemi A. ;

Haas, Naomi B. ;

McDermott, David F. ;

Bilen, Mehmet A. ;

Stein, Mark ;

Sosman, Jeffrey A. ;

Alter, Robert ;

Plimack, Elizabeth R. ;

Ornstein, Moshe ;

Hurwitz, Michael ;

Peace, David J. ;

Signoretti, Sabina ;

Denize, Thomas ;

Cimadamore, Alessia ;

Wu, Catherine J. ;

Braun, David ;

Einstein, David ;

Catalano, Paul J. ;

Hammers, Hans .

JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (25) :2913-+

[3] Predictive role of changes in the tumor burden and International Metastatic Renal Cell Carcinoma Database Consortium class during active surveillance for metastatic renal cell carcinoma [J].

Bimbatti, Davide ;

Ciccarese, Chiara ;

Fantinel, Emanuela ;

Sava, Teodoro ;

Massari, Francesco ;

Bisogno, Iolanda ;

Romano, Mario ;

Porcaro, Antonio ;

Brunelli, Matteo ;

Martignoni, Guido ;

Mazzarotto, Renzo ;

Artibani, Walter ;

Tortora, Giampaolo ;

Iacovelli, Roberto .

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, 2018, 36 (12) :526.e13-526.e18

[4] Temporary treatment cessation versus continuation of first-line tyrosine kinase inhibitor in patients with advanced clear cell renal cell carcinoma (STAR): an open-label, non-inferiority, randomised, controlled, phase 2/3 trial [J].

Brown, Janet E. ;

Royle, Kara-Louise ;

Gregory, Walter ;

Ralph, Christy ;

Maraveyas, Anthony ;

Din, Omar ;

Eisen, Timothy ;

Nathan, Paul ;

Powles, Tom ;

Griffiths, Richard ;

Jones, Robert ;

Vasudev, Naveen ;

Wheater, Matthew ;

Hamid, Abdel ;

Waddell, Tom ;

McMenemin, Rhona ;

Patel, Poulam ;

Larkin, James ;

Faust, Guy ;

Martin, Adam ;

Swain, Jayne ;

Bestall, Janine ;

McCabe, Christopher ;

Meads, David ;

Goh, Vicky ;

Wah, Tze Min ;

Brown, Julia ;

Hewison, Jenny ;

Selby, Peter ;

Collinson, Fiona .

LANCET ONCOLOGY, 2023, 24 (03) :213-227

[5] Nivolumab plus Cabozantinib versus Sunitinib for Advanced Renal-Cell Carcinoma [J].

Choueiri, T. K. ;

Powles, T. ;

Burotto, M. ;

Escudier, B. ;

Bourlon, M. T. ;

Zurawski, B. ;

Juarez, V. M. Oyervides ;

Hsieh, J. J. ;

Basso, U. ;

Shah, A. Y. ;

Suarez, C. ;

Hamzaj, A. ;

Goh, J. C. ;

Barrios, C. ;

Richardet, M. ;

Porta, C. ;

Kowalyszyn, R. ;

Feregrino, J. P. ;

Zolnierek, J. ;

Pook, D. ;

Kessler, E. R. ;

Tomita, Y. ;

Mizuno, R. ;

Bedke, J. ;

Zhang, J. ;

Maurer, M. A. ;

Simsek, B. ;

Ejzykowicz, F. ;

Schwab, G. M. ;

Apolo, A. B. ;

Motzer, R. J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (09) :829-841

[6] Cabozantinib plus Nivolumab and Ipilimumab in Renal-Cell Carcinoma [J].

Choueiri, Toni K. ;

Powles, Thomas ;

Albiges, Laurence ;

Burotto, Mauricio ;

Szczylik, Cezary ;

Zurawski, Bogdan ;

Ruiz, Eduardo Yanez ;

Maruzzo, Marco ;

Zaizar, Alberto Suarez ;

Fein, Luis E. ;

Schutz, Fabio A. ;

Heng, Daniel Y. C. ;

Wang, Fong ;

Mataveli, Fabio ;

Chang, Yu-Lin ;

van Kooten Losio, Maximiliano ;

Suarez, Cristina ;

Motzer, Robert J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2023, 388 (19) :1767-1778

[7]

Dason Shawn, 2023, Am Soc Clin Oncol Educ Book, V43, pe390038, DOI 10.1200/EDBK_390038

[8] Extended follow-up from JAVELIN Renal 101: subgroup analysis of avelumab plus axitinib versus sunitinib by the International Metastatic Renal Cell Carcinoma Database Consortium risk group in patients with advanced renal cell carcinoma [J].

Haanen, J. B. A. G. ;

Larkin, J. ;

Choueiri, T. K. ;

Albiges, L. ;

Rini, B. I. ;

Atkins, M. B. ;

Schmidinger, M. ;

Penkov, K. ;

Michelon, E. ;

Wang, J. ;

Mariani, M. ;

di Pietro, A. ;

Motzer, R. J. .

ESMO OPEN, 2023, 8 (03)

[9] Stereotactic Ablative Radiation for Systemic Therapy-na?ve Oligometastatic Kidney Cancer [J].

Hannan, Raquibul ;

Christensen, Michael ;

Christie, Alana ;

Garant, Aurelie ;

Pedrosa, Ivan ;

Robles, Liliana ;

Mannala, Samantha ;

Wang, Chiachien ;

Hammers, Hans ;

Arafat, Waddah ;

Courtney, Kevin ;

Bowman, Isaac A. ;

Sher, David ;

Ahn, Chul ;

Cole, Suzanne ;

Choy, Hak ;

Timmerman, Robert ;

Brugarolas, James .

EUROPEAN UROLOGY ONCOLOGY, 2022, 5 (06) :695-703

[10] Active surveillance of metastatic renal cell carcinoma: Results from a prospective observational study (MaRCC) [J].

Harrison, Michael R. ;

Costello, Brian A. ;

Bhavsar, Nrupen A. ;

Vaishampayan, Ulka ;

Pal, Sumanta K. ;

Zakharia, Yousef ;

Jim, Heather S. L. ;

Fishman, Mayer N. ;

Molina, Ana M. ;

Kyriakopoulos, Christos E. ;

Tsao, Che-Kai ;

Appleman, Leonard J. ;

Gartrell, Benjamin A. ;

Hussain, Arif ;

Stadler, Walter M. ;

Agarwal, Neeraj ;

Pachynski, Russell K. ;

Hutson, Thomas E. ;

Hammers, Hans J. ;

Ryan, Christopher W. ;

Inman, Brant A. ;

Mardekian, Jack ;

Borham, Azah ;

George, Daniel J. .

CANCER, 2021, 127 (13) :2204-2212

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