Long-term remission following esketamine nasal spray sessions in a patient with severe and highly treatment-resistant depression: a single-case report

被引：2

作者：

Arrighi, Lucas ^{[1
]}

Maakaron, Eloise ^{[1
]}

Korchia, Theo ^{[1
]}

Lancon, Christophe ^{[1
]}

Richieri, Raphaelle ^{[1
,2
]}

机构：

[1] St Marguerite Univ Hosp, Publ Assistance Marseille Hosp, Dept Psychiat, Marseille, France

[2] Aix Marseille Univ, Ecole Cent Marseille, Fresnel Inst, Imothep Team,CNRS,UMR 7249, Marseille, France

来源：

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY | 2024年 / 39卷 / 05期

关键词：

case report; esketamine; intranasal; treatment-resistant depression; ORAL ANTIDEPRESSANT; SAFETY; EFFICACY;

D O I：

10.1097/YIC.0000000000000482

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

About 30% of patients with major depressive disorder have treatment-resistant depression (TRD). Recently, intranasal esketamine was approved as a treatment option after the failure of two antidepressant trials. We report a patient with multiresistant depression that was successfully and safely treated with esketamine nasal spray. This 31-year-old inpatient with severe, chronic, and multi-TRD received an acute course of intranasal esketamine (84 mg). Previously, 14 different antidepressants, alone or in potentiation, and several neurostimulation techniques had been unsuccessful. Over 20 bi-weekly sessions, she had no significant adverse effects and was stabilized into remission. During the maintenance phase and 1 year after, she continues to be stable. This case report provides an example of a patient with severe TRD that showed significant improvement after treatment with intranasal esketamine.

引用

页码：323 / 325

页数：3

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