Advancements in Radiogenomics for Clear Cell Renal Cell Carcinoma: Understanding the Impact of BAP1 Mutation

被引：0

作者：

Greco, Federico ^{[1
,2
]}

D'Andrea, Valerio ^{[2
,3
]}

Buoso, Andrea ^{[2
,3
]}

Cea, Laura ^{[2
,3
]}

Bernetti, Caterina ^{[2
,3
]}

Zobel, Bruno Beomonte ^{[2
,3
]}

Mallio, Carlo Augusto ^{[2
,3
]}

机构：

[1] Azienda Sanit Locale Lecce, Dept Radiol, Cittadella Salute, Piazza Filippo Bottazzi 2, I-73100 Lecce, Italy

[2] Univ Campus Biomed Roma, Dept Med & Surg, Res Unit Neurol, Via Alvaro Portillo 21, I-00128 Rome, Italy

[3] Fdn Policlin Univ Campus Biomed, Via Alvaro Portillo 200, I-00128 Rome, Italy

来源：

JOURNAL OF CLINICAL MEDICINE | 2024年 / 13卷 / 13期

关键词：

radiogenomics; radiomics; texture analysis; renal cancer; clear cell renal cell carcinoma; BAP1; TEXTURE ANALYSIS; SURVIVAL; FEATURES; PBRM1;

D O I：

10.3390/jcm13133960

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent advancements in understanding clear cell renal cell carcinoma (ccRCC) have underscored the critical role of the BAP1 gene in its pathogenesis and prognosis. While the von Hippel-Lindau (VHL) mutation has been extensively studied, emerging evidence suggests that mutations in BAP1 and other genes significantly impact patient outcomes. Radiogenomics with and without texture analysis based on CT imaging holds promise in predicting BAP1 mutation status and overall survival outcomes. However, prospective studies with larger cohorts and standardized imaging protocols are needed to validate these findings and translate them into clinical practice effectively, paving the way for personalized treatment strategies in ccRCC. This review aims to summarize the current knowledge on the role of BAP1 mutation in ccRCC pathogenesis and prognosis, as well as the potential of radiogenomics in predicting mutation status and clinical outcomes.

引用

页数：11

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