FTO gene polymorphism and susceptibility to polycystic ovary syndrome: A meta-analysis

被引：1
作者：
Zhang, Chuanhua [1 ]
Yu, Jiali [2 ]
机构：
[1] Huzhou Univ, Huzhou Municipal Hosp 3, Affiliated Hosp, Dept Gynecol, 2088, East Tiaoxi Rd, Huzhou 313000, Zhejiang, Peoples R China
[2] Yiwu Cent Hosp, Dept Gynecol & Obstet, Yiwu, Peoples R China
来源：
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH | 2024年 / 50卷 / 09期
关键词：
fat mass and objectivity associated gene; meta-analysis; polycystic ovary syndrome; polymorphism; BODY-MASS INDEX; FAT MASS; WOMEN; ASSOCIATION; RISK;
D O I：
10.1111/jog.16047
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
AimTo explore the correlation between Fat mass and objectivity associated gene (FTO) rs9939609 polymorphism and susceptibility to polycystic ovary syndrome.MethodsCase-control studies on the relationship between FTO rs9939609 A/T polymorphism and PCOS were searched in PubMed, EMBASE, and Web of Science according to inclusion and exclusion criteria. STATA 12.0 software was conducted for Meta-analysis.ResultsNine case-control studies were included, including 1410 cases in PCOS group and 1223 cases in healthy control group. The results of meta-analysis showed that FTO rs9939609 gene polymorphism was associated with PCOS susceptibility, and the risk of developing PCOS was 1.19 times higher for T alleles carriers than for A alleles carriers, and some similar associations were observed in Asian populations.ConclusionsIn summary, FTO rs9939609 gene polymorphism is significantly associated with PCOS susceptibility, especially in Asian populations.
引用
收藏
页码：1703 / 1712
页数：10
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