Development of cellulose-based films containing salicylic acid for wound dressing applications: Fabrication, properties and in vitro assessment

被引：0

作者：

Sohaimy, Mohd Ibnu Haikal Ahmad ^{[1
]}

Ismail, Muhammad Amir Amzar ^{[1
]}

Khiar, Azwani Sofia Ahmad ^{[1
]}

Sarbon, Norizah Mhd ^{[2
]}

Salim, Nora Salina Md ^{[4
]}

Yahya, Hanis Nadia ^{[3
]}

Isa, Mohd Ikmar Nizam Mohamad ^{[1
,4
]}

机构：

[1] Univ Sains Islam Malaysia, Fac Sci & Technol, Ion & Kinet Mat Res Lab, Energy Mat Consortium,Adv Mat Team, Nilai 71800, Negeri Sembilan, Malaysia

[2] Univ Malaysia Terengganu, Fac Fisheries & Food Sci, Kuala Nerus, Terengganu, Malaysia

[3] Univ Sains Islam Malaysia, Fac Sci & Technol, Food Biotechnol Programme, Bandar Baru Nilai, Negeri Sembilan, Malaysia

[4] Univ Malaysia Terengganu, Fac Sci & Marine Environm, Ion State Anal Lab, Adv Nano Mat,Adv Mat team, Kuala Nerus, Terengganu Daru, Malaysia

来源：

JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS | 2024年 / 39卷 / 04期

关键词：

Wound dressing; biocompatible; 2-hydroxyethyl cellulose; salicylic acid;

D O I：

10.1177/08839115241253560

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A wound dressing is important to ensure an efficient healing process while protecting the wound area. This research study combined 2-hydroxyethyl cellulose (2HEC)-an etherified cellulose derivative with salicylic acid (SA) to develop a single layer and investigate the 2HEC viability as wound dressing material. Nine different samples with different compositions of SA, from 5 wt.% to 40 wt.% (with an interval of 5 wt.%) and one control sample without adding SA were prepared via the solution casting method. The 2HEC-SA films were studied regarding the effects of SA composition on antimicrobial properties (Staphylococcus aureus) via the well-diffusion method. Additionally, degradability, mechanical properties, X-ray diffraction (XRD), and Fourier transform infrared (FTIR) of 2HEC-SA films have also been tested. The strongest antimicrobial effect of 2HEC-SA film was obtained at 40 wt.% with a 16 mm inhibition zone diameter. There was a noticeable decreasing weight loss pattern in the degradation test and the tensile strength of 2HEC-SA film when the composition of salicylic acid is increased. 2HEC-SA film changes phases from amorphous to crystalline starting at 25 wt.% of salicylic acid as seen through XRD, while FTIR shows that complexation of 2HEC and salicylic acid occurred at 1050 cm-1.

引用

页码：251 / 263

页数：13