Advances in Nucleic Acid Universal Influenza Vaccines

被引:1
|
作者
Xu, Liang [1 ]
Ren, Weigang [1 ]
Wang, Qin [1 ]
Li, Junwei [1 ,2 ]
机构
[1] Nanjing Univ Chinese Med, Hosp Nanjing 2, Dept Infect Dis, Nanjing 210003, Peoples R China
[2] Med Innovat Ctr Infect Dis Jiangsu Prov, Nanjing 210003, Peoples R China
基金
中国国家自然科学基金;
关键词
DNA vaccine; mRNA vaccine; influenza virus; universal influenza vaccine; VIRUS; DNA; PROTECTION;
D O I
10.3390/vaccines12060664
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Currently, vaccination with influenza vaccines is still an effective strategy to prevent infection by seasonal influenza virus in spite of some drawbacks with them. However, due to the rapid evolution of influenza viruses, including seasonal influenza viruses and emerging zoonotic influenza viruses, there is an urgent need to develop broad-spectrum influenza vaccines to cope with the evolution of influenza viruses. Nucleic acid vaccines might meet the requirements well. Nucleic acid vaccines are classified into DNA vaccines and RNA vaccines. Both types induced potent cellular and humoral immune responses, showing great promise for the development of universal influenza vaccines. In this review, the current status of an influenza universal nucleic acid vaccine was summarized.
引用
收藏
页数:11
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