Rare oxoisoaporphine alkaloids from Menispermum dauricum with potential anti-inflammatory activity

被引：1

作者：

Guo, Rui ^{[1
,2
,3
]}

Wang, Cun-Lin ^{[1
,2
,3
]}

Cao, Xiao-Juan ^{[1
,2
,3
]}

Yao, Xiao-Juan ^{[1
,2
,3
]}

Qiao, Xin ^{[1
,2
,3
]}

Meng, Ya-Tian ^{[1
,2
,3
]}

Zhang, Tong ^{[1
,2
,3
]}

Zhang, Qiong ^{[1
,2
,3
]}

机构：

[1] Shanxi Med Univ, Sch Pharm, Taiyuan 030001, Peoples R China

[2] Shanxi Med Univ, Med Basic Res Innovat Ctr Chron Kidney Dis, Minist Educ, Taiyuan 030001, Peoples R China

[3] Shanxi Med Univ, Shanxi Prov Key Lab Drug Synth & Novel Pharmaceut, Taiyuan 030001, Peoples R China

来源：

PHYTOCHEMISTRY | 2024年 / 225卷

关键词：

Menispermaceae; Oxoisoaporphine alkaloid; Anti-inflammatory activity; Menispermum dauricum DC; DUAL INHIBITORS; DERIVATIVES; PRINCIPLES; RHIZOMA; PLANTS; DC;

D O I：

10.1016/j.phytochem.2024.114170

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Eleven alkaloids including four previously undescribed oxoisoaporphine alkaloids, menisoxoisoaporphines A-D (1-4), four known analogues (5-8), and three aporphine alkaloids (9-11), were isolated and identified from the rhizomes of Menispermum dauricum. Their structures were elucidated by extensive spectroscopic data and singlecrystal X-ray diffraction analyses. Among them, compounds 1 and 4 were the first samples of oxoisoaporphine with C-6 isopentylamino moiety, and 2 was a rare C-4 methylation product of oxoisoaporphine alkaloid. The in vitro anti-inflammatory activity of compounds 1-11 was performed by evaluating the inhibition of NO level in LPS-induced RAW264.7 macrophages. Among them, compound 4 exhibited the most potent NO inhibition activity with an IC50 value of 1.95 +/- 0.33 mu M. The key structure-activity relationships of those oxoisoaporphine alkaloids for anti-inflammatory effects have been summarized.

引用

页数：7

共 26 条

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