Features of colorectal adenomas among young patients with Lynch syndrome according to path_MMR: Results from the PRED-IdF registry

被引：1

作者：

Alric, Hadrien ^{[1
,11
]}

Coffin, Elise ^{[1
]}

Lekhal, Celine ^{[2
]}

Benusiglio, Patrick R. ^{[3
,7
]}

Dhooge, Marion ^{[4
]}

Colas, Chrystelle ^{[5
]}

Caron, Olivier ^{[6
]}

Cusin, Veronica ^{[7
]}

Becq, Aymeric ^{[3
]}

Robles, Enrique Perez Cuadrado ^{[1
]}

Leenhardt, Romain ^{[3
]}

Perkins, Geraldine ^{[9
,10
]}

Buecher, Bruno ^{[3
]}

Bellanger, Jerome ^{[3
]}

Rahmi, Gabriel ^{[1
]}

Malka, David ^{[6
]}

Laurent-Puig, Pierre ^{[10
]}

Chaussade, Stanislas ^{[4
]}

Benamouzig, Robert ^{[2
]}

Parc, Yann ^{[8
]}

Cellier, Christophe ^{[1
]}

Perrod, Guillaume ^{[1
]}

机构：

[1] Georges Pompidou European Hosp, APHP, Ctr Univ Paris, Dept Gastroenterol & Digest Endoscopy, 20 Rue Leblanc, F-75015 Paris, France

[2] Paris 13 Univ, Avicenne Hosp, Assistance Publ Hop Paris, Dept Gastroenterol, 125 Rue Stalingrad, F-93000 Bobigny, Paris, France

[3] Sorbonne Univ, St Antoine Hosp, AP HP, Endoscopy Unit, 184 Rue Faubourg St-Antoine, F-75012 Paris, France

[4] Hop Cochin, APHP, Ctr Univ Paris, Dept Gastroenterol, 27 Rue Faubourg St-Jacques, F-75014 Paris, France

[5] Inst Curie, Dept Med Oncol, 26 Rue Ulm, F-75005 Paris, France

[6] Inst Gustave Roussy, Dept Med Oncol, 114 Rue Edouard Vaillant, FR-94800 Villejuif, France

[7] Sorbonne Univ, Pitie Salpetriere Hosp, AP HP, Dept Genet, 7-83 Blvd Hop, F-75013 Paris, France

[8] SU Sorbonne Univ, St Antoine Hosp, APHP, Dept Digest Surg, 184 Rue Faubourg St Antoine, F-75012 Paris, France

[9] Georges Pompidou European Hosp, APHP, Ctr Univ Paris, Dept Digest Oncol, 20 Rue Leblanc, F-75015 Paris, France

[10] Georges Pompidou European Hosp, APHP, Dept Oncogenet, Ctr Univ Paris, 20 Rue LEBLANC, F-75015 Paris, France

[11] Georges Pompidou European Hosp, Dept Gastroenterol & Digest Endoscopy, 20 Rue Leblanc, F-75015 Paris, France

来源：

DIGESTIVE AND LIVER DISEASE | 2024年 / 56卷 / 04期

关键词：

Adenoma; Advanced adenoma; Colorectal cancer; Lynch syndrome; Post colonoscopy colorectal cancer; Sessile serrated lesion; HEREDITARY; SURVEILLANCE; CANCER; FAMILIES;

D O I：

10.1016/j.dld.2023.09.010

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background: Lynch syndrome (LS) is the most frequent inherited colorectal cancer syndrome. Aim: To assess the burden of adenoma in LS patients under 50 years-old followed in the PRED-IdF network. Methods: From January 2010 to January 2019, all patients under 50 years of age with a confirmed LS germline mutation were included. The main objective was the description of adenomas characteristics according to path_MMR. Results: We analyzed data from 708 patients (mean age 34.8 +/- 8.6), of which 41.8 % were male. Among these patients, 37.6% had path_MLH1, 45.4% path_MSH2, 13.9% path_MSH6, 2.9% path_PMS2, and 1.2% path_EpCAM. The analysis included 1721 (70.9%) follow-up colonoscopies. A total of 682 adenomas were detected, including 140 (20.5%) advanced adenomas. The adenoma detection rates during the first and follow-up colonoscopies were 19.2% and 20.5%, respectively. Most adenomas were < 10 mm (57.9%), located in the proximal colon (334, 48.9%), and presented as non-polypoid lesions (493, 72.3%). The median growth time for adenomas was 23 months (range 9-114) irrespective of the path_MMR mutation (p = 0.62). Conclusion: LS patients under 50 years of age have a high burden of adenomas, particularly small non-polypoid adenomas located in the proximal colon. These results highlight the need for intensive screening, with a particular focus on the proximal colon. (c) 2023 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

引用

页码：672 / 678

页数：7