The Role of Social Deprivation and Cannabis Use in Explaining Variation in the Incidence of Psychotic Disorders: Findings From the EU-GEI Study

被引：3

作者：

Brink, Vera ^{[1
,2
,41
]}

Andleeb, Humma ^{[2
]}

Gayer-Anderson, Charlotte ^{[3
,4
]}

Arango, Celso ^{[5
]}

Arrojo, Manuel ^{[6
]}

Berardi, Domenico ^{[7
]}

Bernardo, Miquel ^{[8
,9
,10
,11
]}

Bobes, Julio ^{[12
]}

Del-Ben, Cristina Marta ^{[13
]}

Ferraro, Laura ^{[14
]}

de Haan, Lieuwe ^{[15
]}

La Barbera, Daniele ^{[14
]}

La Cascia, Caterina ^{[14
]}

Lasalvia, Antonio ^{[16
]}

Llorca, Pierre-Michel ^{[17
,18
,19
]}

Menezes, Paolo Rossi ^{[20
,21
]}

Pignon, Baptiste ^{[17
,22
,23
,24
]}

Sanjuan, Julio ^{[25
]}

Santos, Jose Luis ^{[26
]}

Selten, Jean-Paul ^{[27
]}

Tarricone, Ilaria ^{[28
]}

Tortelli, Andrea ^{[29
,30
]}

Tripoli, Giada ^{[14
,31
]}

Velthorst, Eva ^{[32
]}

Rutten, Bart P. F. ^{[27
]}

van Os, Jim ^{[27
,31
,33
]}

Quattrone, Diego ^{[14
,34
,35
,36
,37
]}

Murray, Robin M. ^{[31
,34
,35
,36
]}

Jones, Peter B. ^{[38
,39
]}

Morgan, Craig ^{[3
,4
]}

Di Forti, Marta ^{[34
,35
,36
,37
]}

Jongsma, Hannah E. ^{[1
,40
]}

Kirkbride, James B. ^{[2
,38
]}

机构：

[1] Univ Groningen, Univ Ctr Psychiat, Univ Med Ctr Groningen, Dept Psychosis, Groningen, Netherlands

[2] UCL, Div Psychiat, PsyLife Grp, London, England

[3] Kings Coll London, ESRC Ctr Soc & Mental Hlth, London, England

[4] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Hlth Serv & Populat Res, London, England

[5] Univ Complutense, Hosp Gen Univ Gregorio Maranon, Dept Child & Adolescent Psychiat, Inst Psychiat & Mental Hlth,Sch Med ,IiSGM,CIBERSA, Madrid, Spain

[6] Hosp Clin Univ Santiago De Compostela, Ctr Invest Biomed Red Salud Mental, Serv Gallego Salud, affiliated Ctr,Dept Mental Hlth Drug Addict Assist, Santiago De Compostela, Spain

[7] Alma Mater Studiorium Univ Bologna, Bologna, Italy

[8] Hosp Clin Barcelona, Schizophrenia Unit, Barcelona Clin, Barcelona, Spain

[9] Univ Barcelona UB, Inst Neurociencies UBNeuro, Dept Med, Barcelona, Spain

[10] Inst Invest Biomed August Pi i Sunyer IDIBAPS, Barcelona, Spain

[11] CIBERSAM, ISCIII, Barcelona, Spain

[12] Univ Oviedo, Ctr Invest Biomed Red Salud Mental, Sch Med, Dept Med,Psychiat Area, Oviedo, Spain

[13] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Neurosci & Behav, Sao Paulo, Brazil

[14] Univ Palermo, Sect Psychiat, Dept Biomed Neurosci & Adv Diagnost, Palermo, Italy

[15] Univ Amsterdam, Acad Med Ctr, Dept Psychiat, Early Psychosis Sect, Amsterdam, Netherlands

[16] Univ Verona, Sect Psychiat, Dept Neurosci Biomed & Movement, Verona, Italy

[17] Fdn FondaMental, Creteil, France

[18] CMP B CHU, Clermont Ferrand, France

[19] Univ Clermont Auvergne, Clermont Ferrand, France

[20] Univ Sao Paulo, Fac Med, Dept Prevent Med, Sao Paulo, Brazil

[21] Univ Sao Paulo, Nucleo Pesquina Saude Mental Populac, Sao Paulo, Brazil

[22] Univ Paris Est Creteil UPEC, Creteil, France

[23] Hop Univ H Mondor, AP HP, Psychiat Dept, DMU IMPACT, Creteil, France

[24] INSERM, IMRB, Translat Neuropsychiat, Creteil, France

[25] Univ Valencia, Ctr Invest Biomed Red Salud Mental, Sch Med, Dept Psychiat, Valencia, Spain

[26] Serv Psiquiatria Hosp Virgen de la Luz, Dept Psychiat, Cuenca, Spain

[27] Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Med Ctr, Maastricht, Netherlands

[28] Alma Mater Studiorium Univ Bologna, Dept Med & Surg Sci, Psychiat Unit, Bologna, Italy

[29] Inst Natl Sante & Rech Med, U955, Creteil, France

[30] Grp Hosp Paris Psychiat Neurosci, Pole Psychiat Precarite, Paris, France

[31] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England

[32] Mental Hlth Org GGZ Noord Holland Noord, Dept Res, Heerhugowaard, Netherlands

[33] Univ Med Ctr Utrecht, Brain Ctr, Utrecht, Netherlands

[34] Mental Hlth Biomed Res Ctr South London, Natl Inst Hlth Res NIHR, London, England

[35] Maudsley NHS Fdn Trust, London, England

[36] Kings Coll London, London, England

[37] Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England

[38] Univ Cambridge, Dept Psychiat, Herchel Smith Bldg Brain & Mind Sci, Cambridge, England

[39] Cambridgeshire & Peterborough Natl Hlth Serv Fdn T, Chesterton Med Ctr, CAMEO Early Intervent Serv, Cambridge, England

[40] Veldzicht Ctr Transcultural Psychiat, Balkbrug, Netherlands

[41] Univ Med Ctr Groningen, Univ Ctr Psychiat CC 30, Hanzepl 1,POB 30-001, NL-9700 RB Groningen, Netherlands

来源：

SCHIZOPHRENIA BULLETIN | 2024年 / 50卷 / 05期

基金：

欧盟地平线“2020”; 美国国家卫生研究院; 英国医学研究理事会;

关键词：

social determinants of health; epidemiology; substance use; social inequality; etiology; RISK; SCHIZOPHRENIA; METAANALYSIS; INDIVIDUALS; ASSOCIATION; URBANICITY; TRENDS;

D O I：

10.1093/schbul/sbae072

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Background and Hypothesis Recent findings suggest the incidence of first-episode psychotic disorders (FEP) varies according to setting-level deprivation and cannabis use, but these factors have not been investigated together. We hypothesized deprivation would be more strongly associated with variation in FEP incidence than the prevalence of daily or high-potency cannabis use between settings.Study Design We used incidence data in people aged 18-64 years from 14 settings of the EU-GEI study. We estimated the prevalence of daily and high-potency cannabis use in controls as a proxy for usage in the population at-risk; multiple imputations by chained equations and poststratification weighting handled missing data and control representativeness, respectively. We modeled FEP incidence in random intercepts negative binomial regression models to investigate associations with the prevalence of cannabis use in controls, unemployment, and owner-occupancy in each setting, controlling for population density, age, sex, and migrant/ethnic group.Study Results Lower owner-occupancy was independently associated with increased FEP (adjusted incidence rate ratio [aIRR]: 0.76, 95% CI: 0.61-0.95) and non-affective psychosis incidence (aIRR: 0.68, 95% CI: 0.55-0.83), after multivariable adjustment. Prevalence of daily cannabis use in controls was associated with the incidence of affective psychoses (aIRR: 1.53, 95% CI: 1.02-2.31). We found no association between FEP incidence and unemployment or high-potency cannabis use prevalence. Sensitivity analyses supported these findings.Conclusions Lower setting-level owner-occupancy and increased prevalence of daily cannabis use in controls independently contributed to setting-level variance in the incidence of different psychotic disorders. Public health interventions that reduce exposure to these harmful environmental factors could lower the population-level burden of psychotic disorders.

引用

页码：1039 / 1049

页数：11

共 26 条

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