Association of methyl donor nutrients dietary intake and sleep disorders in the elderly revealed by the intestinal microbiome

被引：0

作者：

Chen, Qianqian ^{[1
,2
]}

Fan, Rui ^{[1
,2
]}

Song, Lixia ^{[1
,2
]}

Wang, Shuyue ^{[1
,2
]}

You, Mei ^{[1
,2
]}

Cai, Meng ^{[1
,2
]}

Wu, Yuxiao ^{[1
,2
]}

Li, Yong ^{[1
,2
]}

Xu, Meihong ^{[1
,2
]}

机构：

[1] Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China

[2] Peking Univ, Beijing Key Lab Toxicol Res & Risk Assessment Food, Beijing 100191, Peoples R China

来源：

FOOD & FUNCTION | 2024年 / 15卷 / 12期

基金：

北京市自然科学基金;

关键词：

ONE-CARBON METABOLISM; GUT MICROBIOTA; GLYCINE; INSOMNIA;

D O I：

10.1039/d4fo01303d

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Currently, sleep disorders (SD) in the elderly are gaining prominence globally and are becoming a significant public health concern. Methyl donor nutrients (MDNs), such as vitamin B6, vitamin B12, folate, and choline, have been reported to have the potential to improve sleep disorders. Moreover, MDNs help to maintain gut flora homeostasis, and are closely associated with the development of SD. Nevertheless, there has been a lack of comprehensive human studies examining the association between MDNs intake and SD. In our study, we comprehensively evaluated the association between MDNs intake and SD in the elderly and used 16S rRNA gene sequencing to explore the underlying mechanism. We found that the SD group (n = 91) had a lower methyl-donor nutritional quality index (MNQI) and a trend toward lower intake compared to the control group (n = 147). Based on the intestinal microbiome, the beta diversity of the intestinal flora was higher in the high methyl-donor nutritional quality (HQ) group compared to the low methyl-donor nutritional quality (LQ) group, and it was lower in the SD group compared to the control group. This suggests that MDNs may regulate sleep by modulating the abundance distribution of the microbiota. Subsequently, we performed correlation analyses between the relative abundance of the microbiota, MDNs intake, and the Pittsburgh Sleep Quality Index (PSQI), identifying five genera with potential regulatory roles. The KEGG pathway analysis indicated that energy metabolism and one-carbon metabolism might be the pathways through which MDNs modulate sleep. This study offers dietary guidance strategies for managing SD in the elderly and provides insights for targeted microbiota intervention. The study aimed to comprehensively assess the association between methyl donor nutrients dietary intake and sleep disorders in the elderly and to explore the underlying mechanisms based on intestinal flora.

引用

页码：6335 / 6346

页数：13

共 71 条

[1] Flavonoids: Their putative neurologic roles, epigenetic changes, and gut microbiota alterations in Parkinson's disease [J].