Inflammasome-mediated mechanisms of systemic inflammation in COVID-19 and asthma

被引：0
作者：
Vitkina, Tatyana I. [1 ]
Lobova, Tatyana G. [1 ]
Bogomaz, Tamara T. [1 ]
Korableva, Eleonora, V [2 ]
机构：
[1] Inst Med Climatol & Rehabil Therapy, Far Eastern Sci Ctr Physiol & Pathol Respirat, Vladivostok Branch, Vladivostok, Russia
[2] Far Eastern Fed Univ, Vladivostok, Russia
来源：
RUSSIAN OPEN MEDICAL JOURNAL | 2024年 / 13卷 / 02期
关键词：
asthma; COVID-19; inflammasome; NLRP3; INFLAMMASOME; PYROPTOSIS; IL-1-BETA; NEUTROPHILS; ACTIVATION; CONTRIBUTE; AUTOPHAGY; IMMUNITY; RELEASE; DEPENDS;
D O I：
10.15275/rusomj.2024.0201
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The review examines the formation of inflammasome-mediated mechanisms of systemic inflammation in asthma after COVID-19. It provides insight into the clinical and pathophysiological relationship between asthma and COVID-19. The review summarizes information about the role of the NLRP3 inflammasome in the pathogenesis of asthma and describes in detail its manifestations in various asthma phenotypes. Emphasizing the significance of the inflammatory -mediated immune response during coronavirus infection in patients with bronchopulmonary pathology, the review outlines the consequences of hyperactivation of the NLRP3 pathway, leading to increased production of cytokines, the appearance of neutrophil and monocyte-derived traps, induction of pyroptosis and the development of complications.
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页数：10
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