New Series of Ni(II), Cu(II), Zr(IV), Ag(I), and Cd(II) Complexes of Trimethoprim and Diamine Ligands: Synthesis, Characterization, and Biological Studies

被引：3

作者：

Al-Assafe, Amaal Younis ^{[1
]}

Al-Quaba, Rana Abdul Malik Sulaiman ^{[2
]}

机构：

[1] Univ Mosul, Dept Chem, Coll Educ Pure Sci, Mosul 41001, Iraq

[2] Univ Mosul, Dept Chem, Coll Sci, Mosul 41001, Iraq

来源：

INDONESIAN JOURNAL OF CHEMISTRY | 2024年 / 24卷 / 03期

关键词：

antibacterial activity; chelating agent; diamine ligand; mixed ligands; trimethoprim;

D O I：

10.22146/ijc.89167

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New compounds series of [M(TMP)(en)]X center dot nH(2)O and [M(TMP)(PD)]X center dot nH(2)O, where M = Ni2+, Cu2+, Zr4+, Ag+, Cd2+, TMP = trimethoprim, en = ethylenediamine, PD = o-phenylene and X= Cl- or NO3-, were prepared. The compounds were characterized using techniques including melting points, conductance, elemental analysis, FTIR, NMR, and mass spectroscopy. FTIR spectra indicated TMP acted like a bi-dentate ligand, combining via the nitrogen atoms of azomethine and pyrimidine amino groups. Diamine ligands (en or o-PD) are coordinated via two nitrogen atoms. Prepared compounds showed monomeric behavior and adopted a 6-coordinate octahedral geometry based on magnetic susceptibility and UV spectra. Conductivity measurements revealed Zr(IV) compounds were 1:2 conductive, while Ag+ and Cd2+ were 1:1 conductive; Ni2+ and Cu2+ compounds were non-conductive. Antibacterial tests on compounds and ligands against Bacillus subtilis and Staphylococcus aureus demonstrated broad-spectrum antibacterial activity. The mixed metal compounds revealed an observable tendency of antibacterial activity in the order Zr > Cd = Ag > Cu, making Zr(IV) compounds the most biologically active among them against S. aureus (Gram-positive) while the same compounds showed less antibacterial activity against B. subtilis (Gram-negative) than the free ligand.

引用

页码：812 / 821

页数：10

共 37 条

[11]

Albahadly H.H., Al-Haidery N.H., Al-Salami. B.K., Synthesis, biological activity trimethoprim derivative and the complexes, J. Phys.: Conf. Ser, 2063, 1, (2021)

[12]

Albedair L.A., Iron(III), gold(III), platinum(IV) and palladium(II) trimethoprim drugs complexes: Synthesis, spectroscopy, morphology and anticancer assessments, Rev. Roum. Chim, 65, 12, pp. 1145-1152, (2020)

[13]

Gulcan M., Sonmez M., Berber I., Synthesis, characterization, and antimicrobial activity of a new pyrimidine Schiff base and its Cu(II), Ni(II), Co(II), Pt(II), and Pd(II) complexes, Turk. J. Chem, 36, (2012)

[14]

Ahmed E.M., Marzouk N.A., Hessien S.A., Ali A.M., Synthesis, reactions and antimicrobial activity of some new thienopyridine and thienopyrimidine derivatives, World J. Chem, 6, 1, pp. 25-31, (2011)

[15]

Mohan C., Kumar V., Kumari N., Kumari S., Yadav J., Gandass T., Yadav S., Synthesis, characterization and antibacterial activity of semicarbazide based Schiff bases and their Pb(II), Zr(IV) and U(VI) complexes, Adv. J. Chem., Sect. B, 2, 4, pp. 187-196, (2020)

[16]

Al-Mukhtar S.E., Aghwan M.T., Synthesis and characterization of 3-methoxypropyldithiocarbamate complexes with iron(II), cobalt(II), nickel(II), copper(II) and zinc(II) and their adducts with nitrogen base ligands, Rafidain J. Sci, 24, 7, pp. 50-59, (2013)

[17]

Alajrawy Othman I., Ibraheem Kaiss R., Hadi Huda A., Vanadyl VO(II) with o-phenylenediamine complexes preparation and spectral characterization, Res. J. Chem. Environ, 23, pp. 43-49, (2019)

[18]

Khanmetov A.A., Hajiyeva K.S., Khamiyev M.J., Alieva R.V., Azizbeyli H.R., Ahmedbekova S.F., Synthesis of zirconyl naphthenates on the basis of oil acids and their applying as complex catalytical systems in the process of oligomerization (polymerization) of ethylene, Azerb. Chem. J, 3, pp. 91-98, (2018)

[19]

Eugene-Osoikhia T.T., Akinpelu I.O., Odiaka T.I., Synthesis, characterization and antimicrobial studies of transition metal complexes of Schiff base derived from salicylaldehyde and L-tyrosine amino acid, Niger, J. Chem. Res, 24, 1, pp. 46-56, (2019)

[20]

Hammoda R.G., Shaalan N., Synthesis of Zn(II) and Co(II) complexes with a Schiff base derived from malonic acid dihydrazide for photo-stabilizers of polystyrene, Indones. J. Chem, 23, 5, pp. 1324-1340, (2023)

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