New Series of Ni(II), Cu(II), Zr(IV), Ag(I), and Cd(II) Complexes of Trimethoprim and Diamine Ligands: Synthesis, Characterization, and Biological Studies

被引：3

作者：

Al-Assafe, Amaal Younis ^{[1
]}

Al-Quaba, Rana Abdul Malik Sulaiman ^{[2
]}

机构：

[1] Univ Mosul, Dept Chem, Coll Educ Pure Sci, Mosul 41001, Iraq

[2] Univ Mosul, Dept Chem, Coll Sci, Mosul 41001, Iraq

来源：

INDONESIAN JOURNAL OF CHEMISTRY | 2024年 / 24卷 / 03期

关键词：

antibacterial activity; chelating agent; diamine ligand; mixed ligands; trimethoprim;

D O I：

10.22146/ijc.89167

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New compounds series of [M(TMP)(en)]X center dot nH(2)O and [M(TMP)(PD)]X center dot nH(2)O, where M = Ni2+, Cu2+, Zr4+, Ag+, Cd2+, TMP = trimethoprim, en = ethylenediamine, PD = o-phenylene and X= Cl- or NO3-, were prepared. The compounds were characterized using techniques including melting points, conductance, elemental analysis, FTIR, NMR, and mass spectroscopy. FTIR spectra indicated TMP acted like a bi-dentate ligand, combining via the nitrogen atoms of azomethine and pyrimidine amino groups. Diamine ligands (en or o-PD) are coordinated via two nitrogen atoms. Prepared compounds showed monomeric behavior and adopted a 6-coordinate octahedral geometry based on magnetic susceptibility and UV spectra. Conductivity measurements revealed Zr(IV) compounds were 1:2 conductive, while Ag+ and Cd2+ were 1:1 conductive; Ni2+ and Cu2+ compounds were non-conductive. Antibacterial tests on compounds and ligands against Bacillus subtilis and Staphylococcus aureus demonstrated broad-spectrum antibacterial activity. The mixed metal compounds revealed an observable tendency of antibacterial activity in the order Zr > Cd = Ag > Cu, making Zr(IV) compounds the most biologically active among them against S. aureus (Gram-positive) while the same compounds showed less antibacterial activity against B. subtilis (Gram-negative) than the free ligand.

引用

页码：812 / 821

页数：10

共 37 条

[1]

Eugene-Osoikhia T.T., Ojeyemi S.A., Akong R.A., Oyetunde T., Onche E.U., Ayeni F., Synthesis, characterisation and antimicrobial studies of metal(II) complexes of trimethoprim and 2,2'-bipyridin heterocycle, Niger, Res. J. Chem. Sci, 9, 1, pp. 273-295, (2021)

[2]

Ikpeazu O.V., Otuokere I.E., Igwe K.K., Determination of stability constant of trimethoprim-Zn(II) complex at different temperatures by continuous variation method, Int. J. Novel Res. Phys. Chem. Math, 7, 2, pp. 1-7, (2020)

[3]

Akinyele O.F., Adejayan S.B., Durosinmi L.M., Ayeni A.O., Ajayeoba T.A., Interactions of metal ions with trimethoprim and metformin, Int. J. ChemTech Res, 13, 2, pp. 38-46, (2020)

[4]

Lawal A., Ayanwale P.A., Obaleye J.A., Rajee A.O., Babamale H.F., Lawal M., Synthesis, characterization and biological studies of mixed ligands nicotinamide-trimethoprim complexes, Int. J. Chem. Mater. Environ. Res, 4, 1, pp. 97-101, (2017)

[5]

Ahmed F.J., AbdAlqader B.S., Haddad R.A., Abed R.R., Saleh M.Y., Preparation and diagnosis of Zn(II), Cd(II) and Hg(II) complexes with Schiff base ligand derived from trimethoprim, Egypt, J. Chem, 65, 10, pp. 359-366, (2022)

[6]

Hassan Z.M., Alattar R.A., Abass S.K., Mihsen H.H., Abbas Z.F., Hussain K.A., Synthesis, characterization and biological activity of mixed ligand (imine of benzidine and 1,10-phenanthroline) complexes with Fe(II), Co(II), Ni(II) and Cu(II), Chem. Chem. Technol, 16, 1, pp. 15-24, (2022)

[7]

Kim H.Y., Kang H.G., Kim H.M., Jeong H.J., Antitumor activity of trimethoprim-sulfamethoxazole against melanoma skin cancer through triggering allergic reaction and promoting immunity, Int. Immunopharmacol, 123, (2023)

[8]

Olagboye S.A., Adebawore A.A., Synthesis, characterization, and antimicrobial studies of mixed ligand complexes of acetanilide and ampicillin with cobalt(II) and nickel(II) ions, Global Sci. J, 9, 11, pp. 1327-1338, (2021)

[9]

Bhowmick A.C., Dev Nath B., Moim M.I., Coordination complexes of transition metals and Schiff base with potent medicinal activity, Am. J. Chem, 9, 4, pp. 109-114, (2019)

[10]

Olagboye S.A., Synthesis, characterization and antimicrobial activities of mixed ligand metals complexes with trimethoprim and potassium thiocyanate, Eur. J. Appl. Sci, 10, 1, pp. 428-439, (2022)

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