Virulence Factors and Carbapenem-Resistance Mechanisms in Hypervirulent Klebsiella Pneumoniae

被引：6

作者：

Liao, Yiqun ^{[1
]}

Gong, Junjie ^{[1
]}

Yuan, Xiaoliang ^{[2
]}

Wang, Xiaoling ^{[1
]}

Huang, Yuanhong ^{[3
]}

Chen, Xiaohong ^{[1
]}

机构：

[1] Gannan Med Univ, Affiliated Hosp 1, Dept Lab Med, 23 Qingnian Rd, Ganzhou 341000, Jiangxi, Peoples R China

[2] Gannan Med Univ, Affiliated Hosp 1, Dept Resp Med, Ganzhou, Peoples R China

[3] Ganzhou Municipal Hosp, Dept Lab Med, 49 Dagong Rd, Ganzhou 341000, Jiangxi, Peoples R China

来源：

INFECTION AND DRUG RESISTANCE | 2024年 / 17卷

关键词：

hypervirulent Klebsiella pneumoniae; virulence factors; plasmid; drug resistance; LIVER-ABSCESS; HYPERMUCOVISCOSITY PHENOTYPE; CLINICAL CHARACTERISTICS; MOLECULAR EPIDEMIOLOGY; GENE; BACTEREMIA; STRAINS; PREVALENCE; AEROBACTIN; PLASMID;

D O I：

10.2147/IDR.S461903

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Hypervirulent Klebsiella pneumoniae (hvKP) has emerged as a novel variant of K. pneumoniae , exhibiting distinct phenotypic and genotypic characteristics that confer increased virulence and pathogenicity. It is not only responsible for nosocomial infections but also community-acquired infections, including liver abscesses, endophthalmitis, and meningitis, leading to significant morbidity and mortality. HvKP has been reported all over the world, but it is mainly prevalent in Asia Pacific, especially China. Moreover, hvKP can acquire carbapenemase genes resulting in the emergence of carbapenem-resistant hypervirulent K. pneumoniae (CR-hvKP), which possesses both high virulence and drug resistance capabilities. Consequently, CR-hvKP poses substantial challenges to infection control and presents serious threats to global public health. In this paper, we provide a comprehensive summary of the epidemiological characteristics, virulence factors, and mechanisms underlying carbapenem resistance in hvKP strains with the aim of valuable for as well as future research.

引用

页码：1551 / 1559

页数：9