Efficient Metal-Free Synthesis of Heterotriarylmethanes by 1,4-Addition of Benzofuran Azadienes

被引:0
作者
Huang, Hong-Li [1 ]
Li, Shan [1 ]
Lv, Yong-Zheng [1 ]
Shi, Ya-Qian [1 ]
Liu, Chang-Bo [2 ]
Peng, Zhongzhong [3 ]
Gao, Fei [4 ]
机构
[1] Liaocheng Univ, Coll Chem & Chem Engn, Liaocheng 252059, Shandong, Peoples R China
[2] Liuyuan St Off Dongchangfu Dist, Liaocheng 252000, Shandong, Peoples R China
[3] Ningbo Hangzhou Bay Hosp, Ningbo 315336, Zhejiang, Peoples R China
[4] Shanghai Univ, Inst Translat Med, Shanghai 200444, Peoples R China
基金
上海市自然科学基金;
关键词
metal-free synthesis; heterocycles; benzofuran azadienes; heterotriarylmethanes; ENANTIOSELECTIVE SYNTHESIS; CONSTRUCTION; DERIVATIVES; INDOLES;
D O I
10.1055/a-2370-6462
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A novel and efficient method has been established for synthesizing a variety of heterotriarylmethanes with good yields by employing a metal-free self-coupling reaction of benzofuran azadienes. The involvement of t-BuONa is essential in this process. Remarkably, this technique boasts mild reaction conditions and exceptional compatibility with various functional groups, rendering it a versatile and invaluable asset in the realm of organic synthesis.
引用
收藏
页码:484 / 487
页数:4
相关论文
共 27 条
  • [1] Triaryl methane derivatives as antiproliferative agents
    Al-Qawasmeh, RA
    Lee, Y
    Cao, MY
    Gu, XP
    Vassilakos, A
    Wright, JA
    Young, A
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (02) : 347 - 350
  • [2] ccdc, CCDC 2327026
  • [3] N-Aminophthalimide-mediated aerobic deborohydroxylation of boronic acid in air
    Chen, Tao
    Zhang, Wenzheng
    Yan, Zhenxing
    Xu, Ze-Feng
    Li, Chuan-Ying
    [J]. ORGANIC CHEMISTRY FRONTIERS, 2024, 11 (02) : 299 - 305
  • [4] Palladium-Catalyzed [4+4] Cycloaddition of Homo-TMM All-Carbon 1,4-Dipole Precursors for Construction of Benzofuro[3,2-b]azocines and Furo[3,2-b]azocines
    Chen, Ying
    Zang, Meng
    Wang, Weijie
    Liu, Yang-Zi
    Luo, Xiaoyan
    Deng, Wei-Ping
    [J]. CHINESE JOURNAL OF CHEMISTRY, 2023, 41 (21) : 2825 - 2831
  • [5] Construction of All-Carbon Quaternary Stereocenters via Sequential Photoactivation/Isothiourea Catalysis
    Fan, Tao
    Zhang, Zi-Jing
    Zhang, Yu-Chen
    Song, Jin
    [J]. ORGANIC LETTERS, 2019, 21 (19) : 7897 - 7901
  • [6] Structure-Activity Relationship of Benzofuran Derivatives with Potential Anticancer Activity
    Farhat, Joviana
    Alzyoud, Lara
    Alwahsh, Mohammad
    Al-Omari, Basem
    [J]. CANCERS, 2022, 14 (09)
  • [7] Direct Synthesis of 2-Methylbenzofurans from Calcium Carbide and Salicylaldehyde p-Tosylhydrazones
    Fu, Rugang
    Li, Zheng
    [J]. ORGANIC LETTERS, 2018, 20 (08) : 2342 - 2345
  • [8] Enantioselective construction of a 2,2′-bisindolylmethane scaffold via catalytic asymmetric reactions of 2-indolylmethanols with 3-alkylindoles
    Gong, Yu-Xin
    Wu, Qiong
    Zhang, Hong-Hao
    Zhua, Qiu-Ning
    Shi, Feng
    [J]. ORGANIC & BIOMOLECULAR CHEMISTRY, 2015, 13 (29) : 7993 - 8000
  • [9] Cinchona Urea-Catalyzed Asymmetric Sulfa-Michael Reactions: The Bronsted Acid-Hydrogen Bonding Model
    Grayson, Matthew N.
    Houk, K. N.
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2016, 138 (29) : 9041 - 9044
  • [10] Chiral Phosphoric Acid-Catalyzed C6 Functionalization of 2,3-Disubstituted Indoles for Synthesis of Heterotriarylmethanes
    Huang, Wen-Jun
    Ma, Ya-Ya
    Liu, Li-Xia
    Wu, Bo
    Jiang, Guo-Fang
    Zhou, Yong-Gui
    [J]. ORGANIC LETTERS, 2021, 23 (07) : 2393 - 2398