Real-world safety and efficacy of biologics in elderly patients with psoriasis: A multicenter observational study

被引：0

作者：

Ohata, Chika ^{[1
]}

Anezaki, Hisataka ^{[2
]}

Yanase, Tetsuji ^{[3
,4
]}

Katayama, Eri ^{[5
]}

Kaneko, Sakae ^{[6
]}

Saito, Kanami ^{[7
]}

Yamane, Mariko ^{[8
]}

Nakamaru, Sei ^{[9
]}

Tsuruta, Noriko ^{[10
]}

Okazaki, Fusako ^{[11
]}

Ito, Kotaro ^{[12
]}

Kikuchi, Satoko ^{[13
]}

Koike, Yuta ^{[14
]}

Miyagi, Takuya ^{[15
]}

Sugita, Kazunari ^{[16
]}

Nakahara, Takeshi ^{[17
]}

Takezaki, Daiki ^{[18
]}

Saruwatari, Hiroshi ^{[19
]}

Yoshida, Yuichi ^{[20
]}

Yonekura, Kentaro ^{[21
]}

Higashi, Yuko ^{[22
]}

Sawada, Yu ^{[23
]}

Chinuki, Yuko ^{[24
]}

Yamaguchi, Kazuki ^{[25
]}

Imafuku, Shinichi ^{[26
]}

机构：

[1] Osaka Gen Med Ctr, Dept Dermatol, 3-1-56,Bandaihigashi, Sumiyoshi, Osaka 5588558, Japan

[2] Kobe Univ, Grad Sch Med, Social Community Med & Hlth Sci, Kobe, Japan

[3] Kamiyacho Yanase Dermatol Clin, Hiroshima, Japan

[4] Asa Citizens Hosp, Hiroshima City North Med Ctr, Dept Dermatol, Hiroshima, Japan

[5] Kurume Univ, Sch Med, Dept Dermatol, Kurume, Japan

[6] Masuda Red Cross Hosp, Dept Dermatol, Masuda, Japan

[7] Oita Univ, Fac Med, Dept Dermatol, Yufu, Japan

[8] Kawasaki Med Sch, Gen Med Ctr, Dept Dermatol, Okayama, Japan

[9] Kansai Med Univ, Dept Dermatol, Osaka, Japan

[10] Kitakyushu City Yahata Hosp, Div Dermatol, Kitakyushu, Japan

[11] Okayama City Gen Med Ctr, Dept Dermatol, Okayama, Japan

[12] Ito Med Clin, Dermatol, Kitsuki, Japan

[13] Kyushu Cent Hosp, Dept Dermatol, Fukuoka, Japan

[14] Nagasaki Univ, Grad Sch Biomed Sci, Dept Dermatol, Nagasaki, Japan

[15] Univ Ryukyus, Grad Sch Med, Dept Dermatol, Nishihara, Japan

[16] Saga Univ, Fac Med, Dept Internal Med, Div Dermatol, Saga, Japan

[17] Kyushu Univ, Grad Sch Med Sci, Dept Dermatol, Fukuoka, Japan

[18] Okayama Univ, Grad Sch Med, Dept Dermatol, Okayama, Japan

[19] Saruwatari Dermatol Clin, Kagoshima, Japan

[20] Tottori Univ, Fac Med, Dept Med Sensory & Motor Organs, Div Dermatol, Yonago, Japan

[21] Imamura Gen Hosp, Dept Dermatol, Kagoshima, Japan

[22] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Dermatol, Kagoshima, Japan

[23] Univ Occupat & Environm Hlth, Dept Dermatol, Kitakyushu, Japan

[24] Shimane Univ, Fac Med, Dept Dermatol, Izumo, Japan

[25] Saiseikai Futsukaichi Hosp, Dept Dermatol, Fukuoka, Japan

[26] Fukuoka Univ, Fac Med, Dept Dermatol, Fukuoka, Japan

来源：

JOURNAL OF DERMATOLOGY | 2024年 / 51卷 / 12期

关键词：

efficiency; elderly patients; infection; psoriasis; safety; SEVERE PLAQUE PSORIASIS; INFECTION; SURVIVAL; MODERATE; REGISTRY; RISK;

D O I：

10.1111/1346-8138.17385

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Clinical trials of biologics have frequently excluded elderly patients, resulting in inadequate data on their safety and efficacy. Additionally, evidence of their safety and efficacy remains limited, despite some real-world studies. To assess the safety and efficacy of biologics in elderly patients with psoriasis, we compared these outcomes in younger patients using data from the West Japan Psoriasis Registry (WJPR). The WJPR consists of approximately 30 facilities in Western Japan, including various healthcare settings. This study enrolled 1395 patients who participated in the 2022 follow-up survey of the WJPR and were either using or had used biologics during the survey. These included 456 patients in the elderly group (>= 65 years) and 939 patients in the younger group (<65 years). Treatment-ending adverse events (TEAEs) occurred in 15.8% and 11.3% of elderly and younger patients, respectively. The incidence rate per 1000 patient-years (PY) for TEAEs was significantly higher in elderly patients than in younger patients (32.9 vs 23.2, p = 0.0234). Infectious diseases were more prevalent in the elderly group than the younger group; however, no significant difference in the frequency of infectious diseases was found between the two groups (p = 0.0807). Malignant neoplasms occurred significantly more frequently in the elderly group than in the younger group (p = 0.0169). Our results indicate a few concerns about infection when prescribing biologics to elderly patients. Biologics were effective for both elderly and younger patients. We found no significant differences in the proportion of patients with a body surface area score <= 3%, Physician's Global Assessment score 0/1, or Patient's Global Assessment score 0/1, as well as in the mean Dermatology Life Quality Index and the Itch Numerical Rating Scale between the younger and the elderly groups. Overall, our results confirm the appropriateness of using biologics in elderly patients with regard to safety and efficacy.

引用

页码：1634 / 1640

页数：7

共 23 条

[1] Survival of classic and biological systemic drugs in psoriasis: results of the BIOBADADERM registry and critical analysis [J].

Davila-Seijo, P. ;

Dauden, E. ;

Carretero, G. ;

Ferrandiz, C. ;

Vanaclocha, F. ;

Gomez-Garcia, F. -J. ;

Herrera-Ceballos, E. ;

De la Cueva-Dobao, P. ;

Belinchon, I. ;

Sanchez-Carazo, J. -L. ;

Alsina, M. ;

Lopez-Estebaranz, J. -L. ;

Ferran, M. ;

Torrado, R. ;

Carrascosa, J. -M. ;

Llamas, M. ;

Rivera, R. ;

Jimenez-Puya, R. ;

Garcia-Doval, I. .

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2016, 30 (11) :1942-1950

[2] Serious infections among a large cohort of subjects with systemically treated psoriasis [J].

Dobry, Allison S. ;

Quesenberry, Charles P. ;

Ray, G. Thomas ;

Geier, Jamie L. ;

Asgari, Maryam M. .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2017, 77 (05) :838-844

[3] Comparison of long-term drug survival and safety of biologic agents in patients with psoriasis vulgaris [J].

Gniadecki, R. ;

Bang, B. ;

Bryld, L. E. ;

Iversen, L. ;

Lasthein, S. ;

Skov, L. .

BRITISH JOURNAL OF DERMATOLOGY, 2015, 172 (01) :244-252

[4] Risk of Serious Infection With Biologic and Systemic Treatment of Psoriasis Results From the Psoriasis Longitudinal Assessment and Registry (PSOLAR) [J].

Kalb, Robert E. ;

Fiorentino, David F. ;

Lebwohl, Mark G. ;

Toole, John ;

Poulin, Yves ;

Cohen, Arnon D. ;

Goyal, Kavitha ;

Fakharzadeh, Steven ;

Calabro, Stephen ;

Chevrier, Marc ;

Langholff, Wayne ;

You, Yin ;

Leonardi, Craig L. .

JAMA DERMATOLOGY, 2015, 151 (09) :961-969

[5] Epidemiological survey of the psoriasis patients in the Japanese Society for Psoriasis Research from 2013 to 2018 [J].

Kamiya, Koji ;

Oiso, Naoki ;

Kawada, Akira ;

Ohtsuki, Mamitaro .

JOURNAL OF DERMATOLOGY, 2021, 48 (06) :864-875

[6] Infection in an aging population [J].

Kline, Kimberly A. ;

Bowdish, Dawn M. E. .

CURRENT OPINION IN MICROBIOLOGY, 2016, 29 :63-67

[7] Efficacy and Safety of Secukinumab in Elderly Subjects with Moderate to Severe Plaque Psoriasis: A Pooled Analysis of Phase III Studies [J].

Koerber, Andreas ;

Papavassilis, Charis ;

Bhosekar, Vaishali ;

Reinhardt, Maximilian .

DRUGS & AGING, 2018, 35 (02) :135-144

[8] Epidemiology of psoriasis and palmoplantar pustulosis: a nationwide study using the Japanese national claims database [J].

Kubota, Kiyoshi ;

Kamijima, Yukari ;

Sato, Tsugumichi ;

Ooba, Nobuhiro ;

Koide, Daisuke ;

Iizuka, Hajime ;

Nakagawa, Hidemi .

BMJ OPEN, 2015, 5 (01)

[9] Rates of hospitalization for community-acquired pneumonia among US adults: A systematic review [J].

McLaughlin, John M. ;

Khan, Farid L. ;

Thoburn, Elizabeth A. ;

Isturiz, Raul E. ;

Swerdlow, David L. .

VACCINE, 2020, 38 (04) :741-751

[10] Safety of classic and biologic systemic therapies for the treatment of psoriasis in elderly: an observational study from national BIOBADADERM registry [J].

Medina, C. ;

Carretero, G. ;

Ferrandiz, C. ;

Dauden, E. ;

Vanaclocha, F. ;

Gomez-Garcia, F. J. ;

Herrera-Ceballos, E. ;

De la Cueva-Dobao, P. ;

Belinchon, I. ;

Sanchez-Carazo, J. L. ;

Alsina, M. ;

Lopez-Estebaranz, J. L. ;

Ferran, M. ;

Carrascosa, J. M. ;

Torrado, R. ;

Argila, D. ;

Rivera, R. ;

Jimenez-Puya, R. ;

Garcia-Doval, I. .

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2015, 29 (05) :858-864

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