Liver transplantation for intrahepatic cholangiocarcinoma: who, when and how

被引：1
|
作者：
Achurra, Pablo [1 ,2 ]
Fernandes, Eduardo [4 ]
O'Kane, Grainne [3 ]
Grant, Robert [3 ]
Cattral, Mark [1 ]
Sapisochin, Gonzalo [1 ,5 ]
机构：
[1] Univ Toronto, Toronto Gen Hosp, Dept Abdominal Transplant & HPB Surg Oncol, Toronto, ON, Canada
[2] Pontificia Univ Catolica Chile, Dept Digest Surg, Santiago, Chile
[3] Princess Margaret Canc Ctr, Dept Med Oncol & Hematol, Toronto, ON, Canada
[4] Univ Fed Rio de Janeiro, Abdominal Organ Transplantat Sao Lucas Hosp Copaca, Dept Surg, Rio De Janeiro, Brazil
[5] Univ Toronto, Toronto Gen Hosp, Abdominal Transplant & HPB Surg Oncol, Toronto, ON M5G2C4, Canada
来源：
CURRENT OPINION IN ORGAN TRANSPLANTATION | 2024年 / 29卷 / 02期
关键词：
intrahepatic cholangiocarcinoma; liver transplantation; molecular targeted therapies; neoadjuvant systemic therapy; CANCER STUDY-GROUP; NEOADJUVANT; RESECTION; PARADIGM; THERAPY; TRENDS;
D O I：
10.1097/MOT.0000000000001136
中图分类号：
R3 [基础医学]; R4 [临床医学];
学科分类号：
1001 ; 1002 ; 100602 ;
摘要：
Purpose of reviewUsing transplant oncology principles, selected patients with intrahepatic cholangiocarcinoma (iCCA) may achieve long-term survival after liver transplantation. Strategies for identifying and managing these patients are discussed in this review.Recent findingsUnlike initial reports, several modern series have reported positive outcomes after liver transplantation for iCCA. The main challenges are in identifying the appropriate candidates and graft scarcity. Tumor burden and response to neoadjuvant therapies have been successfully used to identify favorable biology in unresectable cases. New molecular biomarkers will probably predict this response in the future. Also, new technologies and better strategies have been used to increase graft availability for these patients without affecting the liver waitlist.SummaryLiver transplantation for the management of patients with unresectable iCCA is currently a reality under strict research protocols. Who is a candidate for transplantation, when to use neoadjuvant and locoregional therapies, and how to increase graft availability are the main topics of this review.
引用
收藏
页码：161 / 171
页数：11
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