Effectiveness of repetitive transcranial magnetic stimulation (rTMS) after acute stroke: A one-year longitudinal randomized trial

被引：84

作者：

Guan, Yu-Zhou ^{[1
,2
]}

Li, Jing ^{[2
,3
]}

Zhang, Xue-Wei ^{[2
,3
,4
]}

Wu, Shuang ^{[1
,2
]}

Du, Hua ^{[1
,2
]}

Cui, Li-Ying ^{[1
,2
,5
]}

Zhang, Wei-Hong ^{[2
,3
]}

机构：

[1] Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Neurol, Beijing, Peoples R China

[2] Chinese Acad Med Sci, Beijing, Peoples R China

[3] Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Radiol, Beijing, Peoples R China

[4] China Meitan Gen Hosp, Dept Intervent Radiol, Beijing, Peoples R China

[5] Chinese Acad Med Sci, Neurosci Ctr, Beijing, Peoples R China

来源：

CNS NEUROSCIENCE & THERAPEUTICS | 2017年 / 23卷 / 12期

基金：

中国国家自然科学基金;

关键词：

acute stroke; barthel Index; fugl-meyer assessment upper limb/lower limb; modified Rank Score; national institutes of health stroke scale; repetitive transcranial magnetic stimulation; MOTOR FUNCTION RECOVERY; ACUTE ISCHEMIC-STROKE; PLASTICITY; DISORDER; CORTEX;

D O I：

10.1111/cns.12762

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Aims: To evaluate the effectiveness of repetitive transcranial magnetic stimulation (rTMS) on motor recovery after stroke using a prospective, double-blind, randomized, sham-controlled study. Methods: Patients with unilateral subcortical infarction in the middle cerebral artery territory within 1 week after onset were enrolled. The patients were randomly divided into an rTMS treatment group and a sham group. We performed high-frequency rTMS or sham rTMS on the two groups. Motor functional scores were assessed pre- and post-rTMS/sham rTMS and at 1 month, 3 months, 6 months, and 1 year after stroke onset. The scores included the National Institutes of Health Stroke Scale (NIHSS), Barthel Index (BI), Fugl-Meyer Assessment Upper Limb/Lower Limb (FMA-UL/LL), modified Rank Score (mRS), and the resting motor threshold (RMT) of the hemiplegic limb. Results: At baseline, no significant differences were found between the two groups for motor functional scores. On the second day after rTMS treatment, score improvements of the NIHSS, BI, FMA-UL in the real treatment group were more significant than those in the sham group. In addition, similar results were obtained at 1 month. However, at 3 months, 6 months, and 1 year after onset, no significant differences in improvement were observed between the two groups, except for the FMA-UL score improvement. Conclusion: rTMS facilitates motor recovery of acute stroke patients, and the effect can last to 1 month, except the function improvement on upper extremities could last for 1 year. A single course of rTMS in the acute stage may induce the improvement of upper extremities function lasted for 1 year.

引用

页码：940 / 946

页数：7

共 23 条

[1] Differential Effects of High-Frequency Repetitive Transcranial Magnetic Stimulation Over Ipsilesional Primary Motor Cortex in Cortical and Subcortical Middle Cerebral Artery Stroke [J].