Epigenetic signature of very low birth weight in young adult life

被引：1

作者：

Kuula, Juho ^{[1
,2
,3
]}

Czamara, Darina ^{[4
]}

Hauta-alus, Helena ^{[1
,3
,5
,6
,7
,8
]}

Lahti, Jari ^{[9
]}

Hovi, Petteri ^{[1
]}

Miettinen, Maija E. ^{[1
]}

Ronkainen, Justiina ^{[10
]}

Eriksson, Johan G. ^{[11
,12
,13
,14
]}

Andersson, Sture ^{[3
,7
]}

Jarvelin, Marjo-Riitta ^{[10
,15
]}

Sebert, Sylvain

Raikkonen, Katri ^{[9
]}

Binder, Elisabeth B. ^{[4
]}

Kajantie, Eero ^{[1
,3
,7
,16
,17
]}

机构：

[1] Finnish Inst Hlth & Welf, Populat Hlth Res, Helsinki, Finland

[2] Univ Helsinki, HUS Med Imaging Ctr, Dept Radiol, Helsinki, Finland

[3] Helsinki Univ Hosp, Helsinki, Finland

[4] Max Planck Inst Psychiat, Dept Translat Res Psychiat, Munich, Germany

[5] Oulu Univ Hosp, PEDEGO Res Unit, MRC Oulu, Oulu, Finland

[6] Univ Oulu, Oulu, Finland

[7] Univ Helsinki, Childrens Hosp, Pediat Res Ctr, Helsinki, Finland

[8] Univ Helsinki, Fac Med, Res Program Clin & Mol Metab, Helsinki, Finland

[9] Univ Helsinki, Dept Psychol & Logoped, Helsinki, Finland

[10] Univ Oulu, Ctr Life Course Hlth Res, Oulu, Finland

[11] Folkhalsan Res Ctr, Topeliusgatan 20, Helsinki 00250, Finland

[12] Agcy Sci Technol & Res, Singapore Inst Clin Sci, Singapore, Singapore

[13] Natl Univ Singapore, Dept Obstet & Gynaecol, Singapore, Singapore

[14] Natl Univ Singapore, Yong Loo Lin Sch Med, Human Potential Translat Res Programme, Singapore, Singapore

[15] Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

[16] Univ Oulu, Clin Med Res Unit, Oulu, Finland

[17] Norwegian Univ Sci & Technol, Dept Clin & Mol Med, Trondheim, Norway

来源：

PEDIATRIC RESEARCH | 2025年 / 97卷 / 01期

基金：

芬兰科学院;

关键词：

DNA METHYLATION; PRETERM BIRTH; GENE; EXPRESSION; STRESS; PROTEINS; EXPOSURE; SOCS1;

D O I：

10.1038/s41390-024-03354-6

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Background: Globally, one in ten babies is born preterm (<37 weeks), and 1-2% preterm at very low birth weight (VLBW, <1500 g). As adults, they are at increased risk for a plethora of health conditions, e.g., cardiometabolic disease, which may partly be mediated by epigenetic regulation. We compared blood DNA methylation between young adults born at VLBW and controls. Methods: 157 subjects born at VLBW and 161 controls born at term, from the Helsinki Study of Very Low Birth Weight Adults, were assessed for peripheral venous blood DNA methylation levels at mean age of 22 years. Significant CpG-sites (5'-C-phosphate-G-3') were meta-analyzed against continuous birth weight in four independent cohorts (pooled n = 2235) with cohort mean ages varying from 0 to 31 years. Results: In the discovery cohort, 66 CpG-sites were differentially methylated between VLBW adults and controls. Top hits were located in HIF3A, EBF4, and an intergenic region nearest to GLI2 (distance 57,533 bp). Five CpG-sites, all in proximity to GLI2, were hypermethylated in VLBW and associated with lower birth weight in the meta-analysis. Conclusion: We identified differentially methylated CpG-sites suggesting an epigenetic signature of preterm birth at VLBW present in adult life.

引用

页码：229 / 238

页数：10