Anti-inflammatory activity of some medicinal plants extracts commonly used in traditional medicine in healthy and diabetic rats

Inflammation is a protective immune system reaction that guards the individual against infection. It is a big global issue. many anti-inflammation drugs have side effects. As a result, a different therapy module may be required. Due to their great efficacy and lack of side effects. This study examined the anti-inflammation activity of Rhus coriaria, Globularai arabica, and Malva slyvesitris in diabetic rats with paw edema caused by carrageenan. Rats were separated into two groups: non diabetic and diabetic rats. Each group have five sub groups seven rats/ group. Group 1, treated with saline for non-diabetic and diabetic rats. Groups 2, treated with aspirin as a positive control for non-diabetic and diabetic rats. Groups 3, 4 and 5, were treated orally with pants extract with concentration 50, 100 and 200 mg/kg for non-diabetic and diabetic rats. Il-6 levels were measured in all treated groups after 7 hr of treatment. The results showed that methanolic extracts of R. coriaria and G. arabica at 200 mg/kg significantly (P< 0.01) decreases paw edema in diabetic rats compared with non-diabetic rats (P< 0.01). This resuts may imply that R. coriaria and G. arabica have potent anti-inflammatory properties in response to paw edema. The level of Il-6 was decreased in groups treated with 200 mg/kg R. coriraia and G. arabica indicating high efficacy on anti-inflammatory activity. in addition, M. slyversries has low activity. conclusion, extracts of R. coriaria and G. arabica exhibit anti-inflammatory effect in diabetic rats with paw edema.