Targeting mitochondrial dynamics and redox regulation in cardiovascular diseases

被引：8

作者：

Beg, Mirza Ahmar ^{[1
]}

Huang, Minqi ^{[2
]}

Vick, Lance ^{[3
]}

Rao, K. N. Shashanka ^{[4
,5
]}

Zhang, Jue ^{[1
]}

Chen, Yiliang ^{[1
,6
]}

机构：

[1] Versiti Blood Res Inst, Milwaukee, WI 53226 USA

[2] WuXi AppTec Co, HD Biosci Inc, San Diego, CA 92121 USA

[3] Med Coll Wisconsin, Dept Biochem, Milwaukee, WI 53226 USA

[4] Med Coll Wisconsin, Joint Dept Biomed Engn, Milwaukee, WI 53226 USA

[5] Marquette Univ, Milwaukee, WI 53226 USA

[6] Med Coll Wisconsin, Dept Med, Milwaukee, WI 53226 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2024年 / 45卷 / 04期

关键词：

EXTRACELLULAR VESICLES; FISSION; ATHEROSCLEROSIS; PATHOGENESIS; INFLAMMATION; MACROPHAGES; INHIBITION; ROLES;

D O I：

10.1016/j.tips.2024.02.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Accumulating evidence highlights the pivotal role of mitochondria in cardiovascular diseases (CVDs). Understanding the molecular mechanisms underlying mitochondrial dysfunction is crucial for developing targeted therapeutics. Recent years have seen substantial advancements in unraveling mitochondrial regulatory pathways in both normal and pathological states and the development of potent drugs. However, specific delivery of drugs into the mitochondria is still a challenge. We present recent findings on regulators of mitochondrial dynamics and reactive oxygen species (ROS), critical factors influencing mitochondrial function in CVDs. We also discuss advancements in drug delivery strategies aimed at overcoming the technical barrier in targeting mitochondria for CVD treatment.

引用

页码：290 / 303

页数：14

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