Programmable Readout With Integrated Bandgap Reference Potentiostat for Glucose Sensing

A novel electronics interface which includes programmable readout amplifier and bandgap reference voltage potentiostat circuit for glucose electrochemical sensors is designed and implemented in 0.18- mu m , CMOS process technology and 1.5-V supply voltage. One of the main advantages of the proposed architecture is that it has digitally controlled readout circuit and a bandgap reference voltage potentiostat integrated into a single circuit. The proposed readout circuit, i.e., the programmable transimpedance amplifier (PTIA), offers wide dynamic range and low noise. The PTIA achieves an overall transimpedance gain of 17.3-50.5 k Omega . The linear output voltage range of the PTIA response is 0.55-1.44 V for an input current range of 4.2- 180 mu A . The output rms noise value is obtained to be 5.101 mu V(rm)s and the complete architecture dissipates a total power of 2.33 mW. The % THD varies from 0.5 to 4 for the above specified current range. A 0.6-V reference voltage has been used for all the measurements produced by bandgap reference voltage potentiostat. A glassy carbon electrode (GCE) filled-in coated with CuO/Cu0.76CO2.25O4 (copper cobaltite) is used as the working electrode (WE). The glucose concentration ranges from 1 to 10 mM have been measured by electrochemical glucose sensing setup and the prototyped circuit tested for the practicability of the proposed architecture. The total area of the proposed glucose sensing architecture is 0.0684 mm2.