Flash vacuum pyrolysis of steroid esters

被引：1
|
作者：
Habib, Osama M. [1 ]
Mohamed, Asaad S. [2 ]
Al-Awadi, Nouria A. [2 ]
机构：
[1] Kuwait Univ, Fac Med, Biochem Dept, Kuwait, Kuwait
[2] Kuwait Univ, Fac Sci, Chem Dept, POB 5969, Safat 13060, Kuwait
来源：
JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS | 2024年 / 179卷
关键词：
Flash vacuum pyrolysis; Steroid esters; 2H-cyclohepta[b]furan-2-one; 2H-chromen-2-one; Unsaturated steroids; PREGNENOLONE; DERIVATIVES; ACETATE;
D O I：
10.1016/j.jaap.2024.106491
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
We report here our synthetic approach to acetylenic esters of six different steroids. The use of flash vacuum pyrolysis (FVP) is a very appealing tool for the acetylenic moiety to efficiently cyclize and rearrange which allows access to medicinally and pharmaceutically valuable products. Each substrate was subjected to FVP. The products were analyzed, identified and characterized. Acetylenic esters of aromatic steroids resulted in 2 H - cyclohepta[ b ]furan-2-one, and 2 H -chromen-2-one derivatives, while aliphatic esters afforded unsaturated polycyclic hydrocarbons via elimination of propiolic acid.
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页数：8
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