The CXCR2 chemokine receptor: A new target for gastric cancer therapy

被引：0
作者：
Kang, Wenyan [1 ]
Wang, Chengkun [1 ]
Wang, Minhui [1 ]
Liu, Meiqi [1 ]
Hu, Wei
Liang, Xiaoqiu [1 ]
Zhang, Yang [1 ]
机构：
[1] Univ South China, Hengyang Med Sch, Canc Res Inst, Hunan Prov Key Lab Tumor Cellular & Mol Pathol, Hengyang, Hunan, Peoples R China
来源：
CYTOKINE | 2024年 / 181卷
关键词：
CXCR2; Gastric cancer; Inflammation; Pathway; Therapy; TUMOR-ASSOCIATED MACROPHAGES; IMMATURE MYELOID CELLS; BREAST-CANCER; MELANOMA GROWTH; IN-VITRO; PROMOTES METASTASIS; HUMAN INTERLEUKIN-8; SUPPRESSOR-CELLS; POOR-PROGNOSIS; STEM-CELLS;
D O I：
10.1016/j.cyto.2024.156675
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Gastric cancer (GC) is one of the most common malignant tumors in the world, and current treatments are still based on surgery and drug therapy. However, due to the complexity of immunosuppression and drug resistance, the treatment of gastric cancer still faces great challenges. Chemokine receptor 2 (CXCR2) is one of the most common therapeutic targets in targeted therapy. As a G protein-coupled receptor, CXCR2 and its ligands play important roles in tumorigenesis and progression. The abnormal expression of these genes in cancer plays a decisive role in the recruitment and activation of white blood cells, angiogenesis, and cancer cell proliferation, and CXCR2 is involved in various stages of tumor development. Therefore, interfering with the interaction between CXCR2 and its ligands is considered a possible target for the treatment of various tumors, including gastric cancer.
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页数：11
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  • [81] Macrophages and Therapeutic Resistance in Cancer
    Ruffell, Brian
    Coussens, Lisa M.
    [J]. CANCER CELL, 2015, 27 (04) : 462 - 472
  • [82] Taxane-induced Attenuation of the CXCR2/BCL-2 Axis Sensitizes Prostate Cancer to Platinum-based Treatment
    Ruiz de Porras, Vicenc
    Wang, Xieng C.
    Palomero, Luis
    Marin-Aguilera, Mercedes
    Sole-Blanch, Carme
    Indacochea, Alberto
    Jimenez, Natalia
    Bystrup, Sara
    Bakht, Martin
    Conteduca, Vincenza
    Piulats, Josep M.
    Buisan, Oscar
    Suarez, Jose F.
    Pardo, Juan Carlos
    Castro, Elena
    Olmos, David
    Beltran, Himisha
    Mellado, Begona
    Martinez-Balibrea, Eva
    Font, Albert
    Aytes, Alvaro
    [J]. EUROPEAN UROLOGY, 2021, 79 (06) : 722 - 733
  • [83] Tumor Necrosis Factor-α Blocks Differentiation and Enhances Suppressive Activity of Immature Myeloid Cells during Chronic Inflammation
    Sade-Feldman, Moshe
    Kanterman, Julia
    Ish-Shalom, Eliran
    Elnekave, Mazal
    Horwitz, Elad
    Baniyash, Michal
    [J]. IMMUNITY, 2013, 38 (03) : 541 - 554
  • [84] Phase Ib Pilot Study to Evaluate Reparixin in Combination with Weekly Paclitaxel in Patients with HER-2-Negative Metastatic Breast Cancer
    Schott, Anne F.
    Goldstein, Lori J.
    Cristofanilli, Massimo
    Ruffini, Pier Adelchi
    McCanna, Susan
    Reuben, James M.
    Perez, Raymond P.
    Kato, Giraldo
    Wicha, Max
    [J]. CLINICAL CANCER RESEARCH, 2017, 23 (18) : 5358 - 5365
  • [85] IL-8 activates endothelial cell CXCR1 and CXCR2 through Rho and Rac signaling pathways
    Schraufstatter, IU
    Chung, J
    Burger, M
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2001, 280 (06) : L1094 - L1103
  • [86] Tumour-associated neutrophils in patients with cancer
    Shaul, Merav E.
    Fridlender, Zvi G.
    [J]. NATURE REVIEWS CLINICAL ONCOLOGY, 2019, 16 (10) : 601 - 620
  • [87] Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer
    Shree, Tanaya
    Olson, Oakley C.
    Elie, Benelita T.
    Kester, Jemila C.
    Garfall, Alfred L.
    Simpson, Kenishana
    Bell-McGuinn, Katherine M.
    Zabor, Emily C.
    Brogi, Edi
    Joyce, Johanna A.
    [J]. GENES & DEVELOPMENT, 2011, 25 (23) : 2465 - 2479
  • [88] Epidermal growth factor receptor inhibition downregulates Helicobacter pylori-induced epithelial inflammatory responses, DNA damage and gastric carcinogenesis
    Sierra, Johanna C.
    Asim, Mohammad
    Verriere, Thomas G.
    Piazuelo, M. Blanca
    Suarez, Giovanni
    Romero-Gallo, Judith
    Delgado, Alberto G.
    Wroblewski, Lydia E.
    Barry, Daniel P.
    Peek, Richard M., Jr.
    Gobert, Alain P.
    Wilson, Keith T.
    [J]. GUT, 2018, 67 (07) : 1247 - 1260
  • [89] Host CXCR2-Dependent Regulation of Melanoma Growth, Angiogenesis, and Experimental Lung Metastasis
    Singh, Seema
    Varney, Michelle
    Singh, Rakesh K.
    [J]. CANCER RESEARCH, 2009, 69 (02) : 411 - 415
  • [90] The Immune Microenvironment Confers Resistance to MAPK Pathway Inhibitors through Macrophage-Derived TNFα
    Smith, Michael P.
    Sanchez-Laorden, Berta
    O'Brien, Kate
    Brunton, Holly
    Ferguson, Jennifer
    Young, Helen
    Dhomen, Nathalie
    Flaherty, Keith T.
    Frederick, Dennie T.
    Cooper, Zachary A.
    Wargo, Jennifer A.
    Marais, Richard
    Wellbrock, Claudia
    [J]. CANCER DISCOVERY, 2014, 4 (10) : 1214 - 1229
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