The CXCR2 chemokine receptor: A new target for gastric cancer therapy

被引：0
作者：
Kang, Wenyan [1 ]
Wang, Chengkun [1 ]
Wang, Minhui [1 ]
Liu, Meiqi [1 ]
Hu, Wei
Liang, Xiaoqiu [1 ]
Zhang, Yang [1 ]
机构：
[1] Univ South China, Hengyang Med Sch, Canc Res Inst, Hunan Prov Key Lab Tumor Cellular & Mol Pathol, Hengyang, Hunan, Peoples R China
来源：
CYTOKINE | 2024年 / 181卷
关键词：
CXCR2; Gastric cancer; Inflammation; Pathway; Therapy; TUMOR-ASSOCIATED MACROPHAGES; IMMATURE MYELOID CELLS; BREAST-CANCER; MELANOMA GROWTH; IN-VITRO; PROMOTES METASTASIS; HUMAN INTERLEUKIN-8; SUPPRESSOR-CELLS; POOR-PROGNOSIS; STEM-CELLS;
D O I：
10.1016/j.cyto.2024.156675
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Gastric cancer (GC) is one of the most common malignant tumors in the world, and current treatments are still based on surgery and drug therapy. However, due to the complexity of immunosuppression and drug resistance, the treatment of gastric cancer still faces great challenges. Chemokine receptor 2 (CXCR2) is one of the most common therapeutic targets in targeted therapy. As a G protein-coupled receptor, CXCR2 and its ligands play important roles in tumorigenesis and progression. The abnormal expression of these genes in cancer plays a decisive role in the recruitment and activation of white blood cells, angiogenesis, and cancer cell proliferation, and CXCR2 is involved in various stages of tumor development. Therefore, interfering with the interaction between CXCR2 and its ligands is considered a possible target for the treatment of various tumors, including gastric cancer.
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页数：11
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