KOtBu-Catalyzed Synthesis of Isoindole Derivatives from N-Benzyl Amides Bearing an Ortho Alkynyl Group via 1,2-Acyl Shift

被引：0

作者：

Shimazumi, Ryoma ^{[1
]}

Morimoto, Moe ^{[1
]}

Tobisu, Mamoru ^{[1
,2
]}

机构：

[1] Osaka Univ, Grad Sch Engn, Dept Appl Chem, Osaka 5650871, Japan

[2] Osaka Univ, Inst Open & Transdisciplinary Res Initiat ICS OTRI, Innovat Catalysis Sci Div, Osaka 5650871, Japan

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 26期

关键词：

CYCLIZATION; CHEMISTRY;

D O I：

10.1021/acs.orglett.4c02055

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this study, we present the catalytic conversion of benzylamides featuring an ortho alkynyl moiety into 1-acylisoindole derivatives via a 1,2-acyl shift. Remarkably, this transformation proceeds without the need for transition-metal catalysts; instead, (KOBu)-Bu-t alone serves as the catalyst. This method enables the efficient synthesis of isoindoles from easily accessible amides with an atom economy of 100%.

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收藏

页码：5587 / 5591

页数：5

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