Chronic postsurgical pain

BACKGROUNDChronic postsurgical pain (CPSP) is a clinical problem, and large prospective studies are needed to determine its incidence, characteristics, and risk factors.OBJECTIVETo find predictive factors for CPSP in an international surveyDESIGNObservational studySETTINGMulticentre European prospective observational trialPATIENTSPatients undergoing breast cancer surgery, sternotomy, endometriosis surgery, or total knee arthroplasty (TKA).METHODStandardised questionnaires were completed by the patients at 1, 3, and 7 days, and at 1, 3, and 6 months after surgery, with follow-up via E-mail, telephone, or interview.MAIN OUTCOME MEASUREThe primary goal of NIT-1 was to propose a scoring system to predict those patient likely to have CPSP at 6 months after surgery.RESULTSA total of 3297 patients were included from 18 hospitals across Europe and 2494 patients were followed-up for 6 months. The mean incidence of CPSP at 6 months was 10.5%, with variations depending on the type of surgery: sternotomy 6.9%, breast surgery 7.4%, TKA 12.9%, endometriosis 16.2%. At 6 months, neuropathic characteristics were frequent for all types of surgery: sternotomy 33.3%, breast surgery 67.6%, TKA 42.4%, endometriosis 41.4%. One-third of patients experienced CPSP at both 3 and 6 months. Pre-operative pain was frequent for TKA (leg pain) and endometriosis (abdomen) and its frequency and intensity were reduced after surgery. Severe CPSP and a neuropathic pain component decreased psychological and functional wellbeing as well as quality of life. No overarching CPSP risk factors were identified.CONCLUSIONUnfortunately, our findings do not offer a new CPSP predictive score. However, we present reliable new data on the incidence, characteristics, and consequences of CPSP from a large European survey. Interesting new data on the time course of CPSP, its neuropathic pain component, and CPSP after endometriosis surgery generate new hypotheses but need to be confirmed by further research.TRIAL REGISTRATIONclinicaltrials.gov ID: NCT03834922