Serum high-density lipoprotein cholesterol levels predict early recurrence and prognosis of intrahepatic cholangiocarcinoma after surgical resection

Introduction: Dysregulation in lipid metabolism contributes to the occurrence and development of various cancers. The connection between changes in lipid metabolism and the development of intrahepatic cholangiocarcinoma remains uncertain. Our objective was to investigate the significance of blood lipid levels in patients with intrahepatic cholangiocarcinoma who have undergone surgery. Methods: Ninety-seven ICC patients who underwent surgery were retrospectively enrolled. After 92.2 months of follow-up, the Kaplan -Meier analysis and Cox proportional hazard model were used to calculate overall survival and recurrence -free survival. Results: The median age of this cohort was 56 years, and 79 (81.4 %) of them were male. Eightyeight (90.7 %) patients presented with tumor recurrence and 73 (75.3 %) died. In multivariate analyses, high -density lipoprotein cholesterol level ( <0.91 vs. >= 0.91 mmol/L, hazard ratio [HR] = 2.55; 95 % CI: 1.38 -4.71), lymph node metastasis (Yes vs. No, HR = 2.58; 95 % CI: 1.28 -5.19), etiology factor (chronic HBV infection vs. others, HR = 0.5; 95 % CI: 0.28 -0.88) and multiple tumor lesions (Yes vs. No, HR = 1.85; 95 % CI: 1.01 -3.39) were independent predictors of overall survival. However, only high -density lipoprotein cholesterol level (HR = 1.86; 95 % CI: 1.19 -2.92) emerged as the independent factor for recurrence -free survival. High -density lipoprotein cholesterol level (HR = 2.07; 95 % CI: 1.26 -3.41), etiology factor (HR = 0.49; 95 % CI: 0.29 -0.84), and multiple tumor lesions (HR = 2.00; 95 % CI: 1.14 -3.51) were independent predictors of early recurrence. For patients who did not experience the spread of cancer to the lymph nodes, there was a significant correlation between the level of high -density lipoprotein cholesterol and their overall survival, recurrence -free survival, and early recurrence. For patients with low pre -operation high -density lipoprotein cholesterol levels, high post -operation highdensity lipoprotein cholesterol levels were associated with better prognosis. Conclusions: Low serum high -density lipoprotein cholesterol level might serve as a sign of poor clinical outcomes (overall survival and recurrence -free survival) and early recurrence among intrahepatic cholangiocarcinoma patients. Strengthening the monitoring and intervention of intrahepatic cholangiocarcinoma patients with poor prognosis might be critical for improving the prognosis.