Overweight, Obesity, Hypertriglyceridemia, and Insulin Resistance Are Positively Associated with High Serum Copper Levels in Mexican Adults

被引：2

作者：

Ramirez-Cruz, Armando ^{[1
,2
]}

Rios-Lugo, Maria Judith ^{[3
,4
]}

Soto-Sanchez, Jacqueline ^{[5
]}

Juarez-Perez, Cuauhtemoc Arturo ^{[6
]}

Cabello-Lopez, Alejandro ^{[6
]}

Jimenez-Ramirez, Carmina ^{[7
]}

Chang-Rueda, Consuelo ^{[8
]}

Cruz, Miguel ^{[1
]}

Hernandez-Mendoza, Hector ^{[9
,10
]}

Vazquez-Moreno, Miguel ^{[1
]}

机构：

[1] Hosp Especialidades Ctr Med La Raza, Ctr Med Nacl Siglo 21, Unidad Invest Med Bioquim, Inst Mexicano Seguro Social, Ciudad de Mexico 06720, Mexico

[2] Univ Autonoma Metropolitana, Unidad Iztapalapa, Posgrad Biol Expt, Ciudad De Mexico 09340, Mexico

[3] Univ Autonoma San Luis Potosi, Fac Enfermeria & Nutr, San Luis Potosi 78290, Mexico

[4] Univ Autonoma San Luis Potosi, Ctr Invest Ciencias Salud & Biomed, Secc Med Mol & Traslac, San Luis Potosi 78210, Mexico

[5] Inst Politecn Nacl, Escuela Nacl Med & Homeopatia, Secc Estudios Posgrad Invest, Ciudad De Mexico 07320, Mexico

[6] Inst Mexicano Seguro Social, Ctr Med Nacl Siglo 21, Unidad Invest Salud Trabajo, Ciudad De Mexico 06720, Mexico

[7] Dr Victorio Fuente Narvaez, Inst Mexicano Seguro Social, Unidades Med Alta Especial, Ciudad De Mexico 07760, Mexico

[8] Univ Autonoma Chiapas, Fac Ciencias Quim, Campus IV, Tapachula 30792, Mexico

[9] Univ Autonoma San Luis Potosi, Inst Invest Zonas Desert, Altair 200, San Luis Potosi 78377, Mexico

[10] Univ Ctr Mexico, Lab Agua & Monitoreo Ambiental, San Luis Potosi 78250, Mexico

来源：

METABOLITES | 2024年 / 14卷 / 05期

关键词：

copper; overweight; obesity; hypertriglyceridemia; insulin resistance; Mexico; METABOLIC SYNDROME; DIABETES-MELLITUS; TRACE-ELEMENTS; TRIGLYCERIDES; POPULATION; GLUCOSE; BLOOD; WOMEN; INDEX;

D O I：

10.3390/metabo14050282

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recently, the role of trace elements in the pathophysiology of obesity, insulin resistance (IR), and metabolic diseases has been explored. In this cross-sectional study, we aimed to assess the association of overweight, obesity, and cardiometabolic traits with serum copper (Cu) levels in 346 Mexican adults. Serum Cu level was measured by inductively coupled plasma mass spectrometry (ICP-MS). Anthropometrical data were collected, and biochemical parameters were measured. The triglyceride-glucose (TyG) index was used as a surrogate marker to evaluate IR. Overweight and obesity status was positively associated with the serum Cu level (beta = 19.434 +/- 7.309, p = 0.008). Serum Cu level was observed to have a positive association with serum triglycerides level (beta = 0.160 +/- 0.045, p < 0.001) and TyG (beta = 0.001 +/- 0.001, p < 0.001). Additionally, high serum Cu level was positively associated with overweight and obesity status (odds ratio [OR] = 1.9, 95% confidence interval [95% CI] 1.1-3.4, p = 0.014), hypertriglyceridemia (OR = 3.0, 95% CI 1.7-5.3, p < 0.001), and IR (OR = 2.6, 95% CI 1.4-4.6, p = 0.001). In conclusion, our results suggest that overweight, obesity, hypertriglyceridemia, and IR are positively associated with serum Cu levels in Mexican adults.

引用

页数：11

共 60 条

[1] Adipose tissue and insulin resistance in obese [J].