The regulatory role of m6A modification in the maintenance and differentiation of embryonic stem cells

被引：0

作者：

Zhang, Jin ^{[1
]}

Tong, Lingling ^{[1
]}

Liu, Yuchen ^{[2
]}

Li, Xiang ^{[2
]}

Wang, Jiayi ^{[2
]}

Lin, Ruoxin ^{[2
]}

Zhou, Ziyu ^{[2
]}

Chen, Yunbing ^{[2
]}

Chen, Yanxi ^{[2
]}

Liu, Yirong ^{[3
]}

Chen, Di ^{[1
,4
]}

机构：

[1] Zhejiang Univ, Univ Edinburgh Inst, ZJU UoE Inst,Sch Med, Ctr Reprod Med,Affiliated Hosp 2,Ctr Regenerat & C, Hangzhou 310003, Zhejiang, Peoples R China

[2] Zhejiang Univ, Sch Med, Univ Edinburgh Inst ZJU UoE Inst, Haining 314400, Zhejiang, Peoples R China

[3] Minjiang Univ, Coll Mat & Chem Engn, Fuzhou 350108, Fujian, Peoples R China

[4] Natl Key Lab Biobased Transportat Fuel Technol, Haining 314400, Zhejiang, Peoples R China

来源：

GENES & DISEASES | 2024年 / 11卷 / 05期

基金：

浙江省自然科学基金; 中国国家自然科学基金;

关键词：

Cell-fate transition; Embryonic stem cell; Epigenetic modification; m(6)A modification; Post-transcriptional regulation; MESSENGER-RNA METHYLATION; NUCLEAR-RNA; MOUSE; N-6-METHYLADENOSINE; PLURIPOTENCY; PROTEINS; REVEALS; STATE; N6-METHYLADENOSINE; METHYLTRANSFERASE;

D O I：

10.1016/j.gendis.2023.1011992352-3042

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As the most prevalent and reversible internal epigenetic modification in eukaryotic mRNAs, N-6-methyladenosine (m(6)A) post-transcriptionally regulates the processing and metabolism of mRNAs involved in diverse biological processes. m(6)A modification is regulated by m(6)A writers, erasers, and readers. Emerging evidence suggests that m(6)A modification plays essential roles in modulating the cell-fate transition of embryonic stem cells. Mechanistic investigation of embryonic stem cell maintenance and differentiation is critical for understanding early embryonic development, which is also the premise for the application of embryonic stem cells in regenerative medicine. This review highlights the current knowledge of m(6)A modification and its essential regulatory contribution to the cell fate transition of mouse and human embryonic stem cells.

引用

页数：14

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