Optimization of boronic ester-based amphiphilic copolymers for ROS-responsive drug delivery

被引：1

作者：

Gao, Yuhan ^{[1
]}

Yang, Ruhui ^{[2
,3
]}

Shou, Zeyu ^{[4
]}

Zan, Xingjie ^{[2
,3
,5
]}

Tang, Sicheng ^{[2
,3
,5
]}

机构：

[1] Wenzhou Med Univ, Sch Pharm, Wenzhou 325035, Zhejiang, Peoples R China

[2] Wenzhou Med Univ, Sch Ophthalmol, Wenzhou 325035, Zhejiang, Peoples R China

[3] Wenzhou Med Univ, Optometry Eye Hosp, Sch Biomed Engn, Wenzhou 325035, Zhejiang, Peoples R China

[4] Wenzhou Med Univ, Affiliated Hosp 1, Dept Anesthesia, Wenzhou 325000, Peoples R China

[5] Univ Chinese Acad Sci, Wenzhou Inst, Wenzhou Key Lab Perioperat Med, Wenzhou 325001, Zhejiang, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 52期

关键词：

Compendex;

D O I：

10.1039/d4cc01836b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This study introduces boronic ester-based ROS-responsive amphiphilic copolymers for antioxidant drug delivery. Tuning the hydrophobic/hydrophilic balance optimized the size, curcumin encapsulation, ROS-triggered release, cellular uptake, and intracellular ROS scavenging. The lead P1b formulation self-assembled into stable 10 nm micelles enabling rapid ROS-triggered curcumin release and preferential cellular internalization. P1b eliminated over 90% of pathogenic intracellular ROS within 10 minutes, demonstrating a rapid antioxidant therapy. This study introduces the optimization of boronic ester-based ROS-responsive amphiphilic copolymers for antioxidant drug delivery.

引用

页码：6683 / 6686

页数：4

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