Mechanisms and Barriers in Nanomedicine: Progress in the Field and Future Directions

被引：16

作者：

Anchordoquy, Thomas ^{[1
]}

Artzi, Natalie ^{[2
,3
,4
]}

Balyasnikova, Irina V. ^{[5
,6
]}

Barenholz, Yechezkel ^{[7
]}

La-Beck, Ninh M. ^{[8
]}

Brenner, Jacob S. ^{[9
,10
]}

Chan, Warren C. W. ^{[11
,12
]}

Decuzzi, Paolo ^{[13
]}

Exner, Agata A. ^{[14
,15
]}

Gabizon, Alberto ^{[16
,17
]}

Godin, Biana ^{[18
,19
,20
,21
]}

Lai, Samuel K. ^{[22
]}

Lammers, Twan ^{[23
]}

Mitchell, Michael J. ^{[24
,25
]}

Moghimi, S. Moein ^{[26
,27
,28
]}

Muzykantov, Vladimir R. ^{[29
]}

Peer, Dan ^{[30
,31
,32
]}

Nguyen, Juliane ^{[22
]}

Popovtzer, Rachela ^{[33
,34
]}

Ricco, Madison ^{[1
]}

Serkova, Natalie J. ^{[35
]}

Singh, Ravi ^{[36
,37
]}

Schroeder, Avi ^{[38
]}

Schwendeman, Anna A. ^{[39
,40
]}

Straehla, Joelle P. ^{[41
,42
]}

Teesalu, Tambet ^{[43
]}

Tilden, Scott ^{[1
]}

Simberg, Dmitri ^{[1
]}

机构：

[1] Univ Colorado, Skaggs Sch Pharm & Pharmaceut Sci, Dept Pharmaceut Sci, Anschutz Med Campus, Aurora, CO 80045 USA

[2] Harvard Med Sch, Brigham & Womans Hosp, Dept Med, Div Engn Med, Boston, MA 02215 USA

[3] MIT, Inst Med Engn & Sci, Cambridge, MA 02215 USA

[4] Harvard Univ, Wyss Inst Biolog Inspired Engn, Boston, MA 02215 USA

[5] Northwestern Univ, Feinberg Sch Med, Dept Neurol Surg, Chicago, IL 60611 USA

[6] Northwestern Univ, Lurie Comprehens Canc Ctr, Feinberg Sch Med, Northwestern Med Malnati Brain Tumor Inst, Chicago, IL 60611 USA

[7] Hebrew Univ Jerusalem, Membrane & Liposome Res Lab, IMRIC, Hadassah Med Sch, IL-9112102 Jerusalem, Israel

[8] Texas Tech Univ, Hlth Sci Ctr, Jerry H Hodge Sch Pharm, Dept Immunotherapeut & Biotechnol, Abilene, TX 79601 USA

[9] Univ Penn, Dept Med, Philadelphia, PA 19104 USA

[10] Univ Penn, Dept Pharmacol, Philadelphia, PA 19104 USA

[11] Univ Toronto, Inst Biomed Engn, Toronto, ON M5S 3G9, Canada

[12] Univ Toronto, Terrence Donnelly Ctr Cellular & Biomol Res, Toronto, ON M5S 3E1, Canada

[13] Italian Inst Technol, Lab Nanotechnol Precis Med, I-16163 Genoa, Italy

[14] Case Western Reserve Univ, Dept Radiol, Sch Med, Cleveland, OH 44106 USA

[15] Case Western Reserve Univ, Dept Biomed Engn, Sch Med, Cleveland, OH 44106 USA

[16] Shaare Zedek Med Ctr, Helmsley Canc Ctr, IL-9103102 Jerusalem, Israel

[17] Hebrew Univ Jerusalem, Fac Med, IL-9103102 Jerusalem, Israel

[18] Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA

[19] Houston Methodist Hosp, Dept Obstet & Gynecol, Houston, TX 77030 USA

[20] Weill Cornell Med Coll WCMC, Dept Obstet & Gynecol, New York, NY 10065 USA

[21] Texas A&M, Dept Biomed Engn, College Stn, TX 77843 USA

[22] Univ N Carolina, Eshelman Sch Pharm, Div Pharmacoengn & Mol Pharmaceut, Chapel Hill, NC 27599 USA

[23] Univ Hosp RWTH Aachen, Inst Expt Mol Imaging, Ctr Biohybrid Med Syst, Dept Nanomed & Theranost, D-52074 Aachen, Germany

[24] Univ Penn, Dept Bioengn, Perelman Sch Med, Philadelphia, PA 19104 USA

[25] Univ Penn, Penn Inst RNA Innovat, Perelman Sch Med, Philadelphia, PA 19104 USA

[26] Newcastle Univ, Sch Pharm, Newcastle Upon Tyne NE1 7RU, England

[27] Newcastle Univ, Translat & Clin Res Inst, Fac Hlth & Med Sci, Newcastle Upon Tyne NE2 4HH, England

[28] Univ Colorado, Colorado Ctr Nanomed & Nanosafety, Anschutz Med Campus, Aurora, CO 80045 USA

[29] Univ Penn, Perelman Sch Med, Dept Syst Pharmacol & Translat Therapeut, Philadelphia, PA 19104 USA

[30] Tel Aviv Univ, George S Wise Fac Life Sci, Shmunis Sch Biomed & Canc Res, Lab Precis Nanomed, IL-69978 Tel Aviv, Israel

[31] Tel Aviv Univ, Iby & Aladar Fleischman Fac Engn, Dept Mat Sci & Engn, Ctr Nanosci & Nanotechnol, IL-69978 Tel Aviv, Israel

[32] Tel Aviv Univ, Canc Biol Res Ctr, IL-69978 Tel Aviv, Israel

[33] Bar Ilan Univ, Fac Engn, IL-5290002 Ramat Gan, Israel

[34] Bar Ilan Univ, Inst Nanotechnol & Adv Mat, IL-5290002 Ramat Gan, Israel

[35] Univ Colorado, Dept Radiol, Canc Ctr, Aurora, CO 80045 USA

[36] Wake Forest Univ, Dept Canc Biol, Sch Med, Winston Salem, NC 27101 USA

[37] Atrium Hlth Wake Forest Baptist Comprehens Canc Ct, Winston Salem, NC 27101 USA

[38] Israel Inst Technol, Dept Chem Engn, Technion, IL-32000 Haifa, Israel

[39] Univ Michigan, Coll Pharm, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA

[40] Univ Michigan, Biointerfaces Inst, Ann Arbor, MI 48108 USA

[41] Dana Farber Boston Childrens Canc & Blood Disorder, Boston, MA 02115 USA

[42] MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

[43] Univ Tartu, Inst Biomed & Translat Med, Lab Precis & Nanomed, EE-50411 Tartu, Estonia

来源：

ACS NANO | 2024年 / 18卷 / 22期

基金：

美国国家卫生研究院; 欧盟地平线“2020”; 加拿大自然科学与工程研究理事会; 欧洲研究理事会;

关键词：

nanomedicine; barriers; translation; complement; tumor; inflammation; formulation; delivery; mRNA; PEGYLATED LIPOSOMAL DOXORUBICIN; BLOOD-BRAIN-BARRIER; CONVECTION-ENHANCED DELIVERY; POLYETHYLENE-GLYCOL PEG; MESSENGER-RNA; COMPLEMENT ACTIVATION; THERAPEUTIC-EFFICACY; LIPID NANOPARTICLES; 1ST-LINE TREATMENT; PREEXISTING IGG;

D O I：

10.1021/acsnano.4c00182

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In recent years, steady progress has been made in synthesizing and characterizing engineered nanoparticles, resulting in several approved drugs and multiple promising candidates in clinical trials. Regulatory agencies such as the Food and Drug Administration and the European Medicines Agency released important guidance documents facilitating nanoparticle-based drug product development, particularly in the context of liposomes and lipid-based carriers. Even with the progress achieved, it is clear that many barriers must still be overcome to accelerate translation into the clinic. At the recent conference workshop "Mechanisms and Barriers in Nanomedicine" in May 2023 in Colorado, U.S.A., leading experts discussed the formulation, physiological, immunological, regulatory, clinical, and educational barriers. This position paper invites open, unrestricted, nonproprietary discussion among senior faculty, young investigators, and students to trigger ideas and concepts to move the field forward.

引用

页码：13983 / 13999

页数：17

共 165 条

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Acrotech Biopharma Llc, WITHDRAWAL APPROVAL

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