Unveiling the role of ferroptosis in the progression from NAFLD to NASH: recent advances in mechanistic understanding

被引：6

作者：

Yu, Qian ^{[1
]}

Song, Lixing ^{[1
]}

机构：

[1] Zigong Fourth Peoples Hosp, Lab Med Dept, Zigong, Peoples R China

来源：

FRONTIERS IN ENDOCRINOLOGY | 2024年 / 15卷

关键词：

NAFLD; NASH; lipid peroxidation; pathogenesis; ferroptosis; FATTY LIVER-DISEASE; GLUTATHIONE-PEROXIDASE; 4; NONALCOHOLIC STEATOHEPATITIS; OXIDATIVE STRESS; IRON OVERLOAD; INSULIN-RESISTANCE; CELL-DEATH; PATHOGENESIS; FIBROSIS; GENE;

D O I：

10.3389/fendo.2024.1431652

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Non-alcoholic fatty liver disease (NAFLD) is a prevalent and significant global public health issue. Nonalcoholic steatohepatitis (NASH) represents an advanced stage of NAFLD in terms of pathology. However, the intricate mechanisms underlying the progression from NAFLD to NASH remain elusive. Ferroptosis, characterized by iron-dependent cell death and distinguished from other forms of cell death based on morphological, biochemical, and genetic criteria, has emerged as a potential participant with a pivotal role in driving NAFLD progression. Nevertheless, its precise mechanism remains poorly elucidated. In this review article, we comprehensively summarize the pathogenesis of NAFLD/NASH and ferroptosis while highlighting recent advances in understanding the mechanistic involvement of ferroptosis in NAFLD/NASH.

引用

页数：10

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