Programmed death of cardiomyocytes in cardiovascular disease and new therapeutic approaches

被引:20
作者
Cai, Kexin [1 ]
Jiang, Haoyue [1 ]
Zou, Yuanming [1 ]
Song, Chunyu [1 ]
Cao, Kexin [1 ]
Chen, Shuxian [1 ]
Wu, Yanjiao [1 ]
Zhang, Zhaobo [1 ]
Geng, Danxi [1 ]
Zhang, Naijin [1 ,2 ,3 ]
Liu, Bo [4 ]
Sun, Guozhe [1 ]
Tang, Man [5 ]
Li, Zhao [1 ]
Zhang, Yixiao [6 ]
Sun, Yingxian [1 ,2 ,7 ]
Zhang, Ying [1 ,2 ]
机构
[1] China Med Univ, Dept Cardiol, Hosp 1, 155 Nanjing North St, Shenyang 110001, Liaoning, Peoples R China
[2] China Med Univ, Inst Hlth Sci, 77 Puhe Rd, Shenyang 110001, Liaoning, Peoples R China
[3] China Med Univ, Key Lab Reprod & Genet Med, Natl Hlth Commiss, 77 Puhe Rd, Shenyang 110001, Liaoning, Peoples R China
[4] China Med Univ, Dept Cardiac Surg, Hosp 1, 155 Nanjing North St, Shenyang 110001, Liaoning, Peoples R China
[5] China Med Univ, Coll Pharm, Dept Clin Pharmacol, 77 Puhe Rd, Shenyang 110001, Liaoning, Peoples R China
[6] China Med Univ, Dept Urol Surg, Shengjing Hosp, 36 Sanhao St, Shenyang 110004, Liaoning, Peoples R China
[7] China Med Univ, Key Lab Environm Stress & Chron Dis Control & Pre, Minist Educ, 77 Puhe Rd, Shenyang 110001, Liaoning, Peoples R China
基金
中国国家自然科学基金;
关键词
Programmed cell death; Cardiomyocyte; Cardiovascular diseases; Drug; Treatment; ISCHEMIA-REPERFUSION INJURY; MYOCARDIAL ISCHEMIA/REPERFUSION INJURY; INFLAMMASOME-MEDIATED PYROPTOSIS; ENDOPLASMIC-RETICULUM STRESS; UP-REGULATING AUTOPHAGY; DIABETIC CARDIOMYOPATHY; SIGNALING PATHWAY; CELL-DEATH; NLRP3; INFLAMMASOME; HEART-FAILURE;
D O I
10.1016/j.phrs.2024.107281
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Cardiovascular diseases (CVDs) have a complex pathogenesis and pose a major threat to human health. Cardiomyocytes have a low regenerative capacity, and their death is a key factor in the morbidity and mortality of many CVDs. Cardiomyocyte death can be regulated by specific signaling pathways known as programmed cell death (PCD), including apoptosis, necroptosis, autophagy, pyroptosis, and ferroptosis, etc. Abnormalities in PCD can lead to the development of a variety of cardiovascular diseases, and there are also molecular-level interconnections between different PCD pathways under the same cardiovascular disease model. Currently, the link between programmed cell death in cardiomyocytes and cardiovascular disease is not fully understood. This review describes the molecular mechanisms of programmed death and the impact of cardiomyocyte death on cardiovascular disease development. Emphasis is placed on a summary of drugs and potential therapeutic approaches that can be used to treat cardiovascular disease by targeting and blocking programmed cell death in cardiomyocytes.
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页数:23
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