Biological Applications of Thiourea Derivatives: Detailed Review

被引:11
作者
Agili, Fatimah A. [1 ]
机构
[1] Jazan Univ, Coll Sci, Dept Phys Sci, Chem Div, POB 114, Jazan 45142, Saudi Arabia
来源
CHEMISTRY-SWITZERLAND | 2024年 / 6卷 / 03期
关键词
thiourea; antibacterial; antioxidant; anticancer; anti-inflammatory; anti-Alzheimer; antimalaria; HIGH-THROUGHPUT EXPERIMENTATION; CELL-CYCLE ARREST; ANTIMICROBIAL ACTIVITY; ANTICANCER AGENTS; COMPLEXES; ANALOGS; ANTIBACTERIAL; CYTOTOXICITY; DISCOVERY; ANTIMALARIAL;
D O I
10.3390/chemistry6030025
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Thiourea and its derivatives have become a significant focal point within the organic synthesis field, garnering attention for their diverse biological applications, including antibacterial, antioxidant, anticancer, anti-inflammatory, anti-Alzheimer, antituberculosis and antimalarial properties. My objective is to present a comprehensive and easily understandable analysis of recent advancements in the organic synthesis of thiourea derivatives. My focus is on the structure and activity of these derivatives over the past five years, highlighting the significant progress made in the field of organic synthesis. Additionally, I evaluate the current state of research in this area and provide an overview of the latest trends and future prospects. This review will prove to be beneficial for researchers, academics and industry professionals involved in drug development and organic synthesis.
引用
收藏
页码:435 / 468
页数:34
相关论文
共 113 条
[61]  
Mertschenk B., 2002, ULLMANNS ENCY IND CH, DOI [10.1002/14356007.a26803, DOI 10.1002/14356007.A26803]
[62]  
Mishra A, 2013, CURR TOP MED CHEM, V13, P2011
[63]   A retrospect on antimicrobial potential of thiazole scaffold [J].
Mishra, Isha ;
Mishra, Raghav ;
Mujwar, Somdutt ;
Chandra, Phool ;
Sachan, Neetu .
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2020, 57 (06) :2304-2329
[64]  
Mohamed A.E., 2023, Molecules, V28, P6420
[65]   Recent advances in gold-NHC complexes with biological properties [J].
Mora, Malka ;
Concepcion Gimeno, M. ;
Visbal, Renso .
CHEMICAL SOCIETY REVIEWS, 2019, 48 (02) :447-462
[66]   SYNTHESIS, CHARACTERIZATION AND UREASE INHIBITION STUDIES OF TRANSITION METAL COMPLEXES OF THIOUREAS BEARING IBUPROFEN MOIETY [J].
Mumtaz, Amara ;
Arshad, Jahanzaib ;
Saeed, Aamer ;
Nawaz, Muhammad Azhar Hyat ;
Iqbal, Jamshed .
JOURNAL OF THE CHILEAN CHEMICAL SOCIETY, 2018, 63 (02) :3934-3940
[67]   A critical review on recent trends on pharmacological applications of pyrazolone endowed derivatives [J].
Mustafa, Ghulam ;
Zia-ur-Rehman, Muhammad ;
Sumrra, Sajjad Hussain ;
Ashfaq, Muhammad ;
Zafar, Wardha ;
Ashfaq, Maryam .
JOURNAL OF MOLECULAR STRUCTURE, 2022, 1262
[68]   Synthesis, characterization, and pharmacological evaluation of thiourea derivatives [J].
Naz, Sumaira ;
Zahoor, Muhammad ;
Umar, Muhammad Naveed ;
Alghamdi, Saad ;
Sahibzada, Muhammad Umar Khayam ;
UlBari, Wasim .
OPEN CHEMISTRY, 2020, 18 (01) :764-777
[69]  
Nedeljkovic N, 2022, Med Sci Forum. Basel Switzerland: MDPI, V14, P28, DOI [10.3390/ECMC2022-13279, DOI 10.3390/ECMC2022-13279]
[70]   Synthesis and Investigation of Anti-Inflammatory Activity of New Thiourea Derivatives of Naproxen [J].
Nedeljkovic, Nikola ;
Dobricic, Vladimir ;
Boskovic, Jelena ;
Vesovic, Marina ;
Bradic, Jovana ;
Andic, Marijana ;
Kocovic, Aleksandar ;
Jeremic, Nevena ;
Novakovic, Jovana ;
Jakovljevic, Vladimir ;
Vujic, Zorica ;
Nikolic, Milos .
PHARMACEUTICALS, 2023, 16 (05)