Diagnostic Value of SALL4 and OCT3/4 in Pediatric Testicular Tumors

被引:2
作者
Bica, Ovidiu [1 ]
Ciongradi, Carmen Iulia [1 ]
Ivanuta, Marius [2 ]
Ianole, Victor [3 ]
Sarbu, Ioan [1 ]
Cojocaru, Elena [3 ]
Bica, Delia Elena [4 ]
Lozneanu, Ludmila [5 ]
机构
[1] Grigore T Popa Univ Med & Pharm, Dept Surg Pediat Surg & Orthoped 2, Iasi 700115, Romania
[2] Grigore T Popa Univ Med & Pharm, Dept Urol, Iasi 700115, Romania
[3] Grigore T Popa Univ Med & Pharm, Dept Morphofunct Sci Pathol 1, Iasi 700115, Romania
[4] Grigore T Popa Univ Med & Pharm, Dept Clin Pharmacol, Iasi 700115, Romania
[5] Grigore T Popa Univ Med & Pharm, Dept Morphofunct Sci Histol 1, Iasi 700115, Romania
关键词
pediatric; testicular; tumors; immunohistochemistry; SALL4; OCT3/4; GERM-CELL NEOPLASIA; EXPRESSION; OCT4; MARKERS;
D O I
10.3390/diagnostics14131454
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Testicular tumors (TTs) are rare in children, posing diagnostic and therapeutic challenges. This retrospective study evaluates the diagnostic and prognostic utility of SALL4 and OCT3/4 in pediatric TTs. We analyzed 18 cases of different types of TTs using immunohistochemistry (IHC) to assess SALL4 (Spalt-like transcription factor 4) and OCT3/4 (Octamer binding transcription factor 3/4) expression. SALL4 was positive in 83.3% of tumors, while OCT3/4 was positive in 38.9% of tumors, with a significantly higher prevalence in patients aged 12-18 years compared to those aged 0-11 years (p = 0.013). Mixed germinal cell tumors were significantly more frequently associated with OCT3/4 (p = 0.003), and a high immunostaining expression for SALL4 was observed primarily in yolk sac tumors and embryonal carcinoma. Our findings suggest that SALL4 and OCT3/4 immunostaining can aid in accurate diagnosis and treatment planning, and underscores the importance of OCT3/4 as a predictive factor in pediatric testicular tumors, highlighting its substantial correlation with tumor type and its impact on treatment response. These markers may guide personalized therapeutic strategies, potentially improving patient outcomes.
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页数:10
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