DLBCL arising from indolent lymphomas: How are they different?

被引：11

作者：

Parry, Erin M. ^{[1
,2
,3
]}

Roulland, Sandrine ^{[4
]}

Okosun, Jessica ^{[5
,6
,7
]}

机构：

[1] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA USA

[2] Harvard Med Sch, Boston, MA USA

[3] Broad Inst MIT & Harvard, Cambridge, MA USA

[4] Aix Marseille Univ, Ctr Immunol Marseille Luminy, CNRS, INSERM, Marseille, France

[5] Queen Mary Univ London, Barts Canc Inst, Ctr Haematooncol, London, England

[6] St Bartholomews Hosp, Dept Haematooncol, London, England

[7] Queen Mary Univ London, Barts Canc Inst, Ctr Haematooncol, Translat Canc Res, London EC1M 6BQ, England

来源：

SEMINARS IN HEMATOLOGY | 2023年 / 60卷 / 05期

关键词：

Transformation; Diffuse large B-cell lymphoma; Follicular lymphoma; CLL; Waldenstr & ouml; m macroglobulinemia; Marginal zone lymphoma; CHRONIC-LYMPHOCYTIC-LEUKEMIA; B-CELL LYMPHOMA; FOLLICULAR LYMPHOMA; HISTOLOGICAL TRANSFORMATION; RICHTER SYNDROME; GRADE TRANSFORMATION; GENOMIC LANDSCAPE; RISK-FACTORS; COPY-NUMBER; OUTCOMES;

D O I：

10.1053/j.seminhematol.2023.11.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Transformation to diffuse large B-cell lymphoma (DLBCL) is a recognized, but unpredictable, clinical inflection point in the natural history of indolent lymphomas. Large retrospective studies highlight a wide variability in the incidence of transformation across the indolent lymphomas and the adverse outcomes associated with transformed lymphomas. Opportunities to dissect the biology of transformed indolent lymphomas have arisen with evolving technologies and unique tissue collections enabling a growing appreciation, particularly, of their genetic basis, how they relate to the preceding indolent lymphomas and the comparative biology with de novo DLBCL. This review summarizes our current understanding of both the clinical and biological aspects of transformed lymphomas and the outstanding questions that remain. (c) 2023 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )

引用

页码：277 / 284

页数：8

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