C3 Dominant Collapsing Focal Segmental Glomerulosclerosis - A Report of Two Rare Cases

被引：0

作者：

Shankar, Mythri ^{[1
,2
]}

Gurusiddiah, Sreedhara C. ^{[1
]}

Vinay, K. S. ^{[1
]}

Aralapuram, Kishan ^{[1
]}

Siddalingappa, Ranjitha ^{[1
]}

Satheesh, Gouri ^{[1
]}

机构：

[1] Inst Nephrourol, Dept Nephrol, Bengaluru, Karnataka, India

[2] 926,Anugraha,Ground Floor,22nd Cross,HSR Layout5th, Bangalore 560102, Karnataka, India

来源：

INDIAN JOURNAL OF NEPHROLOGY | 2024年 / 34卷 / 01期

关键词：

C3; glomerulopathy; collapsing FSGS; NEPHROPATHY; COMPLEMENT;

D O I：

10.4103/ijn.ijn_250_22

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Collapsing focal segmental glomerulosclerosis (FSGS) a heterogeneous group of disorders, rather than a single disease entity. Kidney biopsy shows segmental or globally collapsed, sclerotic glomerular capillaries. There is also hypertrophy and hyperplasia of overlying glomerular epithelial cells. Immuno-fluorescence is negative or has non-specific deposits of immunoglobulins and C3. We present two cases of C3 dominant collapsing FSGS. Both the cases were non -responsive to therapy and had a poor outcome. This calls for research to study the role of the complement pathway in the pathogenesis of FSGS.

引用

页码：70 / 73

页数：4

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