C3 Dominant Collapsing Focal Segmental Glomerulosclerosis - A Report of Two Rare Cases

被引：0
|
作者：
Shankar, Mythri [1 ,2 ]
Gurusiddiah, Sreedhara C. [1 ]
Vinay, K. S. [1 ]
Aralapuram, Kishan [1 ]
Siddalingappa, Ranjitha [1 ]
Satheesh, Gouri [1 ]
机构：
[1] Inst Nephrourol, Dept Nephrol, Bengaluru, Karnataka, India
[2] 926,Anugraha,Ground Floor,22nd Cross,HSR Layout5th, Bangalore 560102, Karnataka, India
来源：
INDIAN JOURNAL OF NEPHROLOGY | 2024年 / 34卷 / 01期
关键词：
C3; glomerulopathy; collapsing FSGS; NEPHROPATHY; COMPLEMENT;
D O I：
10.4103/ijn.ijn_250_22
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Collapsing focal segmental glomerulosclerosis (FSGS) a heterogeneous group of disorders, rather than a single disease entity. Kidney biopsy shows segmental or globally collapsed, sclerotic glomerular capillaries. There is also hypertrophy and hyperplasia of overlying glomerular epithelial cells. Immuno-fluorescence is negative or has non-specific deposits of immunoglobulins and C3. We present two cases of C3 dominant collapsing FSGS. Both the cases were non -responsive to therapy and had a poor outcome. This calls for research to study the role of the complement pathway in the pathogenesis of FSGS.
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收藏
页码：70 / 73
页数：4
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