Mortality of Peritoneal Dialysis versus Hemodialysis in Older Adults: An Updated Systematic Review and Meta-Analysis

被引:1
作者
Cheng, Linan [1 ,2 ,3 ,4 ]
Hu, Nan [1 ,2 ,3 ,4 ]
Song, Di [1 ,2 ,3 ,4 ]
Chen, Yuqing [1 ,2 ,3 ,4 ]
机构
[1] Peking Univ First Hosp, Renal Div, Beijing, Peoples R China
[2] Peking Univ, Inst Nephrol, Beijing, Peoples R China
[3] Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
[4] Minist Educ China, Key Lab CKD Prevent & Treatment, Beijing, Peoples R China
关键词
Chronic kidney insufficiency; Older adults; Hemodialysis; Meta-analysis; Peritoneal dialysis; CHRONIC KIDNEY-DISEASE; STAGE RENAL-DISEASE; COMPARING MORTALITY; PATIENT SURVIVAL; ELDERLY PATIENTS; SIMILAR OUTCOMES; MODALITY; COMORBIDITY; THERAPY; CHOICE;
D O I
10.1159/000536648
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Introduction: The optimal choice of dialysis modality remains contentious in older adults threatened by advanced age and high risk of comorbidities. Methods: We conducted a systematic review and meta-analysis of cohort and case-control studies to assess mortality risk between peritoneal dialysis (PD) and hemodialysis (HD) in older adults using PubMed, Embase, and the Cochrane Library database from inception to June 1, 2022. The outcome of interest is all-cause mortality. Results: Thirty-one eligible studies with >774,000 older patients were included. Pooled analysis showed that PD had a higher mortality rate than HD in older dialysis population (HR 1.17, 95% CI: 1.10-1.25). When stratified by co-variables, our study showed an increased mortality risk of PD versus HD in older patients with diabetes mellitus or comorbidity who underwent longer dialysis duration (more than 3 years) or who started dialysis before 2010. However, definitive conclusions were constrained by significant heterogeneity. Conclusion: From the survival point of view, caution is needed to employ PD for long-term use in older populations with diabetes mellitus or comorbid conditions. However, a tailored treatment choice needs to take account of what matters to older adults at an individual level, especially in the context of limited survival improvements and loss of quality of life. Further research is still awaited to conclude this topic.
引用
收藏
页码:461 / 478
页数:18
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